PMID- 11170743
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20220408
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 71
IP  - 3
DP  - 2001 Feb 1
TI  - A second susceptibility gene for developing rheumatoid arthritis in the human MHC 
      is localized within a 70-kb interval telomeric of the TNF genes in the HLA class 
      III region.
PG  - 263-70
AB  - Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with a 
      multifactorial genetic basis. However, pathogenic genes for RA other than the 
      human leukocyte antigen (HLA)-DRB1 gene have yet to be identified. Here, we 
      investigated whether there is a second susceptibility locus for RA within the 
      human major histocompatibility complex using 18 microsatellite markers 
      distributed from the centromeric (HSET) to the telomeric end (P5-15) of the 
      3.6-Mb HLA region. Statistical studies of associated alleles on each 
      microsatellite locus showed that one pathogenic gene for RA in the HLA region is 
      localized in the DRB1 gene, as expected. Further, a second susceptibility gene of 
      RA was suggested to be present in the HLA class III region, narrowed to 70 kb, 
      that is just telomeric of the TNF gene cluster (TNFA and LTA) and that is located 
      between the microsatellites TNFa and C1-2-A. In this critical segment, four 
      expressed genes have been thus far identified, NFKBIL1 (IkappaBL), ATP6G, BAT1, 
      and MICB, all of which are candidate genes for determining susceptibility to RA. 
      These results exclude the possibility of involvement of the TNFA genes 
      (TNF-alpha) in the development of RA, which was suggested previously to be a 
      strong candidate for RA in the class III region.
CI  - Copyright 2001 Academic Press.
FAU - Ota, M
AU  - Ota M
AD  - Institute of Organ Transplants, Reconstructive Medicine, and Tissue Engineering, 
      Department of Legal Medicine, Shinshu University Graduate School of Medicine, 
      Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, Japan.
FAU - Katsuyama, Y
AU  - Katsuyama Y
FAU - Kimura, A
AU  - Kimura A
FAU - Tsuchiya, K
AU  - Tsuchiya K
FAU - Kondo, M
AU  - Kondo M
FAU - Naruse, T
AU  - Naruse T
FAU - Mizuki, N
AU  - Mizuki N
FAU - Itoh, K
AU  - Itoh K
FAU - Sasazuki, T
AU  - Sasazuki T
FAU - Inoko, H
AU  - Inoko H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alleles
MH  - Arthritis, Rheumatoid/*genetics
MH  - Centromere/metabolism
MH  - Chromosome Mapping
MH  - Genes, MHC Class I
MH  - Genes, MHC Class II
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - *Major Histocompatibility Complex
MH  - Microsatellite Repeats
MH  - Models, Genetic
MH  - Phenotype
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Telomere/genetics
MH  - Tumor Necrosis Factor-alpha/genetics
EDAT- 2001/02/15 11:00
MHDA- 2001/07/13 10:01
CRDT- 2001/02/15 11:00
PHST- 2001/02/15 11:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/02/15 11:00 [entrez]
AID - S0888-7543(00)96371-7 [pii]
AID - 10.1006/geno.2000.6371 [doi]
PST - ppublish
SO  - Genomics. 2001 Feb 1;71(3):263-70. doi: 10.1006/geno.2000.6371.