PMID- 11171651
OWN - NLM
STAT- MEDLINE
DCOM- 20010322
LR  - 20200930
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 280
IP  - 3
DP  - 2001 Mar
TI  - Myocardial adrenergic and cholinergic receptor function in hypoxia: correlation 
      with O(2) transport in exercise.
PG  - R730-8
AB  - The time course of changes in rat myocardial alpha(1)- and beta-adrenoceptors and 
      of muscarinic cholinergic (M-Ach) receptor characteristics was studied parallel 
      with the changes in exercise systemic O(2) transport during a 21-day period of 
      hypoxia (barometric pressure 380 Torr) to assess the effects of receptor 
      modification during acclimatization on maximal exercise capacity. Hypoxia 
      resulted in polycythemia, pulmonary hypertension, right ventricular hypertrophy, 
      and transient left ventricular weight loss. Maximal O(2) consumption at 30 min of 
      hypoxia was reduced to 60% of the normoxic value and remained unchanged. This was 
      partly due to a gradual decrease in maximal cardiac output and heart rate 
      (HR(max)), which offset the increase in blood O(2) content. HR(max) correlated 
      positively (r = 0.994) with beta-adrenoceptor density and negatively (r = -0.964) 
      with M-Ach-receptor density, suggesting that HR(max) reduction results from 
      intrinsic changes in myocardial receptor characteristics leading to reduced 
      responses to adrenergic stimulation and elevated responses to cholinergic 
      stimulation. alpha-Adrenoceptor density in both ventricles increased initially to 
      eventually fall below normoxic values. The dissociation between the different 
      patterns of right and left ventricular weight and the similar pattern of 
      alpha-adrenoceptor change in both ventricles do not support a role for these 
      receptors on right ventricular myocardial hypertrophy.
FAU - Favret, F
AU  - Favret F
AD  - Laboratoire Reponses Cellulaires et Fonctionnelles a l'Hypoxie, EA 2363, 
      Association pour la Recherche en Physiologie de l'Environnement, Universite Paris 
      XIII, 93017 Bobigny, France.
FAU - Richalet, J P
AU  - Richalet JP
FAU - Henderson, K K
AU  - Henderson KK
FAU - Germack, R
AU  - Germack R
FAU - Gonzalez, N C
AU  - Gonzalez NC
LA  - eng
GR  - HL-39443/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Receptors, Adrenergic)
RN  - 0 (Receptors, Adrenergic, alpha-1)
RN  - 0 (Receptors, Adrenergic, beta)
RN  - 0 (Receptors, Muscarinic)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Acclimatization
MH  - Animals
MH  - Blood Pressure
MH  - Body Weight
MH  - Cardiac Output
MH  - Heart Rate
MH  - Heart Ventricles/anatomy & histology/metabolism
MH  - Hypoxia/*physiopathology
MH  - Kinetics
MH  - Male
MH  - Myocardium/*metabolism
MH  - Organ Size
MH  - Oxygen/administration & dosage/blood
MH  - *Oxygen Consumption
MH  - Physical Exertion/*physiology
MH  - Pulmonary Artery/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Adrenergic/*metabolism
MH  - Receptors, Adrenergic, alpha-1/metabolism
MH  - Receptors, Adrenergic, beta/metabolism
MH  - Receptors, Muscarinic/*metabolism
MH  - Vascular Resistance
EDAT- 2001/02/15 11:00
MHDA- 2001/03/27 10:01
CRDT- 2001/02/15 11:00
PHST- 2001/02/15 11:00 [pubmed]
PHST- 2001/03/27 10:01 [medline]
PHST- 2001/02/15 11:00 [entrez]
AID - 10.1152/ajpregu.2001.280.3.R730 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2001 Mar;280(3):R730-8. doi: 
      10.1152/ajpregu.2001.280.3.R730.