PMID- 11172498
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20191111
IS  - 1084-8592 (Print)
IS  - 1084-8592 (Linking)
VI  - 5
IP  - 4
DP  - 2000 Dec
TI  - Automated mass spectrometry: a revolutionary technology for clinical diagnostics.
PG  - 341-8
AB  - For various diagnostic analyses and the studies of functional genomics, the use 
      of an accurate and cost-effective analytic platform to analyze large numbers of 
      samples is essential. An automated platform called MassArray (Sequenom, Inc, San 
      Diego, CA), designed for high-throughput diagnostic analyses, has recently been 
      validated. The platform combines miniaturized, two-dimensional chip arrays with 
      proven high-fidelity enzymatic procedures and matrix-assisted 
      laser-desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. 
      Nanoliter dispensing of samples in high-density formats of 384 or greater results 
      in improved throughput and reduced costs. Automation prevails from the initial 
      assay design through sample processing and data analysis, for the most part 
      eliminating the labor component of assay development and implementation. The 
      MassArray platform is being used in the following areas: (1) molecular diagnosis 
      of genetic disease and infectious agents, (2) pharmacogenomics, (3) paternity 
      and/or identity testing, and (4) agriculture (e.g., marker-assisted breeding). 
      MALDI-TOF mass spectrometry can also be used for analyzing proteins; therefore, 
      genotype/phenotype testing can be performed on a single platform.
FAU - Leushner, J
AU  - Leushner J
AD  - Sequenom, Inc, 11555 Sorrento Valley Rd., San Diego, CA 92121, USA. 
      jleushner@sequenom.com
FAU - Chiu, N H
AU  - Chiu NH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mol Diagn
JT  - Molecular diagnosis : a journal devoted to the understanding of human disease 
      through the clinical application of molecular biology
JID - 9614965
RN  - 0 (Hemoglobin, Sickle)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chromosome Mapping/instrumentation/methods
MH  - DNA Fingerprinting/instrumentation/methods
MH  - Diagnosis, Computer-Assisted/*methods
MH  - Genotype
MH  - Hemoglobin, Sickle/genetics
MH  - Humans
MH  - Male
MH  - Mass Spectrometry/*instrumentation/*methods
MH  - Middle Aged
MH  - Paternity
MH  - Polymorphism, Single Nucleotide/genetics
EDAT- 2001/02/15 11:00
MHDA- 2001/05/01 10:01
CRDT- 2001/02/15 11:00
PHST- 2001/02/15 11:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/02/15 11:00 [entrez]
AID - S1084859200869556 [pii]
AID - 10.1007/BF03262095 [doi]
PST - ppublish
SO  - Mol Diagn. 2000 Dec;5(4):341-8. doi: 10.1007/BF03262095.