PMID- 11172620
OWN - NLM
STAT- MEDLINE
DCOM- 20010621
LR  - 20190605
IS  - 1107-3756 (Print)
IS  - 1107-3756 (Linking)
VI  - 7
IP  - 2
DP  - 2001 Feb
TI  - Development of anorexia in concanavalin A-induced hepatitis in mice.
PG  - 169-72
AB  - Anorexia that develops in chronic hepatitis is associated with cytokine 
      expression in the brain. Treatment of mice with concanavalin A (12.5 mg/kg, i.v.) 
      elevated the plasma alanine aminotransferase activity at 8.5 h after treatment. 
      Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta mRNA expression was 
      induced at 6 and 24 h after concanavalin A treatment in both the liver and brain. 
      Treatment of mice with concanavalin A reduced the body weight at 24 h after 
      treatment and this decreased body weight was accompanied by a decreased food 
      intake. Glycyrrhizin (200 mg/kg, i.p.) inhibited the concanavalin A-induced 
      elevation of plasma alanine aminotransferase activity, however, it did not 
      inhibit the concanavalin A-induced decreased body weight. The present results 
      indicate that treatment of mice with concanavalin A caused the development of 
      anorexia and that this anorexia might develop independently of the induction of 
      hepatitis.
FAU - Okamoto, T
AU  - Okamoto T
AD  - Research Laboratories, Nippon Chemiphar Co., Ltd, 1-22 Hikokawato, Misato, 
      Saitama 341-0005, Japan.
FAU - Okabe, S
AU  - Okabe S
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Interleukin-1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11028-71-0 (Concanavalin A)
RN  - 6FO62043WK (Glycyrrhizic Acid)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/blood/drug effects
MH  - Animals
MH  - Anorexia/*etiology
MH  - Body Weight/drug effects
MH  - Brain/metabolism
MH  - Chemical and Drug Induced Liver Injury/*complications/etiology
MH  - Concanavalin A/administration & dosage/*toxicity
MH  - Disease Models, Animal
MH  - Eating/drug effects
MH  - Female
MH  - Glycyrrhizic Acid/pharmacology
MH  - Hepatitis, Animal/chemically induced/*complications
MH  - Interleukin-1/genetics
MH  - Liver/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - RNA, Messenger/drug effects/metabolism
MH  - Tumor Necrosis Factor-alpha/genetics
EDAT- 2001/02/15 11:00
MHDA- 2001/06/22 10:01
CRDT- 2001/02/15 11:00
PHST- 2001/02/15 11:00 [pubmed]
PHST- 2001/06/22 10:01 [medline]
PHST- 2001/02/15 11:00 [entrez]
AID - 10.3892/ijmm.7.2.169 [doi]
PST - ppublish
SO  - Int J Mol Med. 2001 Feb;7(2):169-72. doi: 10.3892/ijmm.7.2.169.