PMID- 11174025
OWN - NLM
STAT- MEDLINE
DCOM- 20010419
LR  - 20171101
IS  - 1660-8151 (Print)
IS  - 1660-8151 (Linking)
VI  - 87
IP  - 1
DP  - 2001 Jan
TI  - Prognosis of renal amyloidosis: a clinicopathological study using cluster 
      analysis.
PG  - 42-9
AB  - Progression of renal amyloidosis is associated with severe proteinuria or 
      nephrotic syndrome, and various mechanisms have been postulated to explain these 
      complications. We studied the acceleration of proteinuria and reduced renal 
      function by cluster analysis using clinical parameters, renal histological 
      findings, type of renal amyloidosis and follow-up data. We divided 97 cases into 
      three groups of renal amyloidosis. Accelerated progression correlated with serum 
      creatinine (s-Cr) levels at renal biopsy and histological grade of renal damage 
      by amyloid deposition (p < 0.0001). The most influential prognostic factors (s-Cr 
      level > or =2.0 mg/dl) were tubulointerstitial and vascular damage induced by 
      amyloid deposition at biopsy (odds ratio 96.9 and 69.2, respectively). In 
      addition, we found amyloidosis type amyloid associated (AA) correlated with more 
      amyloid-mediated vascular and tubulointerstitial damage than amyloidosis type 
      amyloid light chain (AL) (p < 0.001, p < 0.01, respectively). Proteinuria and 
      nephrotic syndrome were more severe in cases of amyloidosis AL than in 
      amyloidosis AA (p = 0.076). In conclusion, less tubulointerstitial and vascular 
      damage was caused by amyloid deposition; this was slowly progressive. Amyloid AA 
      was detected in tubulointerstitial tissue and vessels more frequently than 
      amyloid AL. Heavy proteinuria and/or nephrosis were not indicators of rapid 
      progression.
CI  - Copyright 2001 S. Karger AG, Basel
FAU - Sasatomi, Y
AU  - Sasatomi Y
AD  - Second Department of Pathology, School of Medicine, Fukuoka University, 45-1 
      Nanakuma 7-chome, Jonan-ku, Fukuoka 814-0133, Japan.
FAU - Kiyoshi, Y
AU  - Kiyoshi Y
FAU - Uesugi, N
AU  - Uesugi N
FAU - Hisano, S
AU  - Hisano S
FAU - Takebayashi, S
AU  - Takebayashi S
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Nephron
JT  - Nephron
JID - 0331777
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amyloidosis/mortality/*pathology
MH  - Biopsy
MH  - Cluster Analysis
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kidney Diseases/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Survival Rate
EDAT- 2001/02/15 11:00
MHDA- 2001/04/21 10:01
CRDT- 2001/02/15 11:00
PHST- 2001/02/15 11:00 [pubmed]
PHST- 2001/04/21 10:01 [medline]
PHST- 2001/02/15 11:00 [entrez]
AID - 45883 [pii]
AID - 10.1159/000045883 [doi]
PST - ppublish
SO  - Nephron. 2001 Jan;87(1):42-9. doi: 10.1159/000045883.