PMID- 11174047
OWN - NLM
STAT- MEDLINE
DCOM- 20010510
LR  - 20171101
IS  - 0302-282X (Print)
IS  - 0302-282X (Linking)
VI  - 43
IP  - 2
DP  - 2001
TI  - The prolonged P(300) latency in recently detoxified alcohol-dependent patients is 
      related to activation of the inflammatory response system.
PG  - 63-9
AB  - The aims of this study were to examine the late components of the auditory 
      event-related potentials (AERPs), i.e. N(100), P(200) and P(300), in recently 
      detoxified alcohol-dependent patients compared to normal controls and to 
      investigate whether there is a relationship between alterations in these AERPs 
      and signs of activation of the inflammatory response system (IRS). The study 
      subjects consisted of 14 healthy volunteers and 14 recently detoxified 
      alcohol-dependent patients. All subjects performed a two-tone auditory 
      discrimination task, using a standard "oddball" paradigm. The alcohol-dependent 
      patients had their blood sampled to examine IRS markers, such as erythrocyte 
      sedimentation rate (ESR), serum copper concentrations and the number of 
      leukocytes. The P(300) latency was significantly greater in recently detoxified 
      alcohol-dependent patients than in normal controls. There were significant 
      correlations between the P(300) latency and the ESR (r = 0.84, p = 0.009), serum 
      copper concentrations (r = 0.73, p = 0.01) and number of monocytes (r = 0.71, p = 
      0.006). It is concluded that the P(300) latency is prolonged in detoxified, 
      chronic alcohol-dependent patients and is positively related to indicators of IRS 
      activation. It is hypothesized that activation of the IRS may play a role in the 
      delayed P(300) latency in recently detoxified, alcohol-dependent patients.
CI  - Copyright 2001 S. Karger AG, Basel
FAU - Maes, M
AU  - Maes M
AD  - Department of Psychiatry and Neuropsychology, University Hospital of Maastricht, 
      Postbus 5800, NL-6202 AZ Maastricht, The Netherlands. crc-mh@online.be
FAU - van West, D
AU  - van West D
FAU - Nuyten, D
AU  - Nuyten D
FAU - Neels, H
AU  - Neels H
FAU - De Vos, N
AU  - De Vos N
FAU - De Bruyne, S
AU  - De Bruyne S
FAU - Degroote, J
AU  - Degroote J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - Alcoholism/*blood/enzymology/immunology/therapy
MH  - *Blood Sedimentation
MH  - Case-Control Studies
MH  - Copper/*blood
MH  - Event-Related Potentials, P300
MH  - *Evoked Potentials, Auditory
MH  - Humans
MH  - Leukocyte Count
MH  - *Leukocytes
MH  - Liver/*enzymology
MH  - Monocytes
MH  - Neutrophils
EDAT- 2001/02/15 11:00
MHDA- 2001/05/22 10:01
CRDT- 2001/02/15 11:00
PHST- 2001/02/15 11:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/02/15 11:00 [entrez]
AID - 54868 [pii]
AID - 10.1159/000054868 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2001;43(2):63-9. doi: 10.1159/000054868.