PMID- 11174148
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20220419
IS  - 1294-9361 (Print)
IS  - 1294-9361 (Linking)
VI  - 2
IP  - 4
DP  - 2000 Dec
TI  - Prognosis in nonconvulsive status epilepticus.
PG  - 185-93
AB  - Determining the prognosis in nonconvulsive status epilepticus (NCSE) is 
      complicated by several factors: under-recognition of NCSE with its spontaneous 
      resolution (thus decreasing the "denominator" of total cases that will have a 
      poor outcome); incorrect diagnosis of NCSE based on misinterpretation of EEG 
      "epileptiform" activity; mis-classification of certain EEG patterns as NCSE (e.g. 
      PLEDs; triphasic waves); and grouping of different populations that have markedly 
      different co-morbidities (ambulatory patients with NCSE together with comatose 
      patients with electrographic seizure activity on EEG). There are almost no 
      prospective studies with premorbid neuropsychometric studies, and retrospective 
      studies typically include isolated cases, or case series that include conditions 
      in which the cause of NCSE itself causes cognitive morbidity. To summarize 
      available data, absence status (ambulatory generalized non-convulsive status 
      epilepticus) would appear to carry no lasting morbidity. Complex partial status 
      epilepticus in ambulatory patients rarely results in measurable permanent 
      neurologic deficit, although rarely, short or long-standing deficits may clearly 
      occur. Because intensive treatment with intravenous anticonvulsants (e.g. 
      benzodiazepines or phenytoin) can confer morbidity, the equation has not yet been 
      made as to whether the morbidity of such intensive treatment for all cases of 
      NCSE exceeds the morbidity of the disease itself. Larger, prospective studies 
      will be needed to truly determine the prognosis in the different types of NCSE, 
      stratified according to associated degrees of impairment (minimally impaired, 
      moderately obtunded, comatose).
FAU - Kaplan, P W
AU  - Kaplan PW
AD  - Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern 
      Avenue, Baltimore, MD 21224, USA. pkaplan@jhmi.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Epileptic Disord
JT  - Epileptic disorders : international epilepsy journal with videotape
JID - 100891853
SB  - IM
MH  - Brain/physiopathology
MH  - Cognition Disorders/etiology
MH  - Electroencephalography
MH  - Humans
MH  - Mental Disorders/etiology
MH  - Prognosis
MH  - Status Epilepticus/complications/*diagnosis/physiopathology
RF  - 68
EDAT- 2001/02/15 11:00
MHDA- 2001/07/13 10:01
CRDT- 2001/02/15 11:00
PHST- 2001/02/15 11:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/02/15 11:00 [entrez]
PST - ppublish
SO  - Epileptic Disord. 2000 Dec;2(4):185-93.