PMID- 11175041
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 15
IP  - 3
DP  - 1998 Apr
TI  - Magnetic Resonance Imaging in Chronic Chagas' Disease: Correlation with 
      Endomyocardial Biopsy Findings and Gallium-67 Cardiac Uptake.
PG  - 279-288
AB  - BACKGROUND: We studied the correlation among cardiac magnetic resonance imaging 
      (MRI), gallium-67 myocardial uptake, and right ventricular endomyocardial biopsy 
      results in chronic Chagas' disease. To our knowledge, this represents the first 
      attempt to correlate the histological findings with cardiac MRI and gallium-67 
      myocardial uptake for noninvasive diagnosis of inflammatory activity associated 
      with Chagas' disease. METHODS: Ten male patients with cardiomyopathy secondary to 
      Chagas' disease were studied (mean age, 47.7 +/- 7 years; congestive heart 
      failure New York Heart Association [NYHA] functional class II [two patients], III 
      [six patients], and IV [two patients]; and mean echocardiographic left 
      ventricular [LV] ejection fraction [EF], 36 +/- 6%). The patients underwent right 
      ventricular endomyocardial biopsy, cardiac MRI, and gallium-67 myocardial uptake 
      testing. The results of this group were compared with those of a control group of 
      patients with idiopathic dilated cardiomyopathy who were matched in age (mean 
      age, 46 +/- 10 years), LV function (mean echocardiographic EF, 30 +/- 4%), and 
      NYHA classification (one patient in class II, five patients in class III, and one 
      patient in class IV). RESULTS: All patients with Chagas' disease showed higher 
      signal intensity on MRI after the administration of gadolinium. The intensity of 
      the septal signal changed from 0.90 +/- 0.11 to 1.56 +/- 0.19 (P < 0.001). In the 
      control group, there was no difference in signal intensity with gadolinium (mean 
      septal intensity, 0.94 +/- 0.12 before and 0.99 +/- 0.15 after; NS). On biopsy, 
      eight chagasic patients had evident signs of myocarditis, and two patients had 
      borderline evidence myocarditis. However, only one patient in the control group 
      had a histological diagnosis of borderline myocarditis. Gallium-67 cardiac uptake 
      was positive for myocardial inflammatory process in seven chagasic patients and 
      borderline in one. On the other hand, only one patient in the control group had 
      an uptake that was positive for inflammation, and one had a borderline result. 
      CONCLUSIONS: In conclusion, the data from this study strongly suggest that 
      myocarditis is frequently found in Chagas' disease. Cardiac MRI appears to be an 
      accurate and alternative method for the diagnosis of inflammatory process 
      associated with Chagas' disease.
FAU - Bocchi, Edimar Alcides
AU  - Bocchi EA
AD  - Rua Oscar Freire numero 2077, apto. 161, Sao Paulo, Brazil, CEP 05409-011.
FAU - Kalil, Roberto
AU  - Kalil R
FAU - Bacal, Fernando
AU  - Bacal F
FAU - de Lourdes Higuchi, Maria
AU  - de Lourdes Higuchi M
FAU - Meneghetti, Claudio
AU  - Meneghetti C
FAU - Magalhaes, Alvaro
AU  - Magalhaes A
FAU - Belotti, Giovanni
AU  - Belotti G
FAU - Ramires, Jose AF
AU  - Ramires JA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
EDAT- 2001/02/15 11:00
MHDA- 2001/02/15 11:01
CRDT- 2001/02/15 11:00
PHST- 2001/02/15 11:00 [pubmed]
PHST- 2001/02/15 11:01 [medline]
PHST- 2001/02/15 11:00 [entrez]
AID - 10.1111/j.1540-8175.1998.tb00608.x [doi]
PST - ppublish
SO  - Echocardiography. 1998 Apr;15(3):279-288. doi: 
      10.1111/j.1540-8175.1998.tb00608.x.