PMID- 11175062
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 15
IP  - 5
DP  - 1998 Jul
TI  - Left Ventricular Diastolic Function in a Population Sample of Elderly Men.
PG  - 433-450
AB  - BACKGROUND AND METHODS: Echocardiography with Doppler has been widely used to 
      assess left ventricular (LV) diastolic function. Interpretation of the diastolic 
      indices that are derived, however, is confounded by the effects of physiological 
      aging on the LV diastolic function. In this study, the usefulness of different 
      Doppler-derived indices of LV diastolic function was assessed in elderly subjects 
      by using data from a health screening survey of 584 men aged 70 years. RESULTS: 
      The index of early versus late transmitral blood flow, the E/A ratio, was found 
      to be reduced in the apparently healthy subgroup (n = 195) of the population 
      (0.96 +/- 0.25) compared with previous data from middle-aged subjects. However, 
      E/A ratios similar to those in the apparently healthy subjects were found in 
      subjects with coronary heart disease (CHD), hypertension, and diabetes mellitus. 
      Only subjects with systolic dysfunction (ejection fraction < 40%) showed a 
      significantly decreased E/A ratio (0.79 +/- 0.21, P < 0.05) compared with the 
      apparently healthy subjects. Isovolumic relaxation time (IVRT) was, however, 
      significantly prolonged in subjects with CHD or hypertension compared with the 
      apparently healthy subjects (139 +/- 32, 127 +/- 25, and 118 +/- 21 milliseconds, 
      respectively; P < 0.01), whereas the E wave deceleration times (DT) were alike in 
      both apparently healthy and unhealthy subjects. The diastolic and systolic 
      components of the pulmonary venous blood flow were alike in apparently healthy 
      and unhealthy subjects. Left atrial size was increased in all patients with 
      disease, possibly indicating increased preload. CONCLUSION: In this population 
      sample of elderly men, the commonly used E/A ratio did not distinguish between 
      apparently healthy subjects and those with cardiovascular diseases such as CHD or 
      hypertension, which are known to be associated with LV diastolic dysfunction in 
      the middle-aged population. IVRT appeared to be the most sensitive of the 
      Doppler-derived indices of LV diastolic function used in the present study, but 
      for this variable, the differences between apparently healthy subjects and 
      unhealthy subjects were small. Thus, the age-associated changes in LV compliance 
      appear to override the impact of these disorders on indices of LV diastolic 
      function in elderly populations.
FAU - Andren, Bertil
AU  - Andren B
AD  - Department of Clinical Physiology, University of Uppsala, Uppsala, Sweden.
FAU - Lind, Lars
AU  - Lind L
FAU - Hedenstierna, Goran
AU  - Hedenstierna G
FAU - Lithell, Hans
AU  - Lithell H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
EDAT- 2001/02/15 11:00
MHDA- 2001/02/15 11:01
CRDT- 2001/02/15 11:00
PHST- 2001/02/15 11:00 [pubmed]
PHST- 2001/02/15 11:01 [medline]
PHST- 2001/02/15 11:00 [entrez]
AID - 10.1111/j.1540-8175.1998.tb00630.x [doi]
PST - ppublish
SO  - Echocardiography. 1998 Jul;15(5):433-450. doi: 
      10.1111/j.1540-8175.1998.tb00630.x.