PMID- 11179368
OWN - NLM
STAT- MEDLINE
DCOM- 20010524
LR  - 20181113
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 69
IP  - 3
DP  - 2001 Mar
TI  - Interference between host resistance to Listeria monocytogenes infection and 
      ovalbumin-induced allergic responses in mice.
PG  - 1883-8
AB  - Listeria monocytogenes promotes the induction of the T-helper 1 (Th1) cell 
      response, while ovalbumin (OVA) induces a Th2 cell response and allergic 
      reactions, such as airway hyperreactivity and immunoglobulin E (IgE) production. 
      When mice were immunized with OVA on day 7 after L. monocytogenes infection, 
      eosinophilia in bronchoalveolar lavage and the production of total IgE, 
      OVA-specific IgE, interleukin-4 (IL-4), and IL-5 in the circulation were markedly 
      suppressed. Cytokine responses, including IL-4, IL-5, IL-10, IL-13, and gamma 
      interferon, to OVA were decreased in the spleen cell cultures obtained from 
      OVA-immunized mice that had been infected with L. monocytogenes. Conversely, when 
      OVA-immunized mice were infected with L. monocytogenes, conversion from the 
      nonlethal infection to the lethal infection occurred. Host resistance to L. 
      monocytogenes infection in OVA-immunized mice was enhanced by the administration 
      of anti-IL-10 monoclonal antibody. The present study indicates that striking 
      interference is observed between Th1-inducing L. monocytogenes infection and 
      Th2-driven OVA-induced airway hyperreactivity.
FAU - Mizuki, D
AU  - Mizuki D
AD  - Department of Bacteriology, School of Medicine, Hirosaki University, Hirosaki, 
      Japan.
FAU - Miura, T
AU  - Miura T
FAU - Sasaki, S
AU  - Sasaki S
FAU - Mizuki, M
AU  - Mizuki M
FAU - Madarame, H
AU  - Madarame H
FAU - Nakane, A
AU  - Nakane A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Antibody Specificity
MH  - Cytokines/analysis
MH  - Eosinophilia
MH  - Female
MH  - Immunity, Innate
MH  - Immunoglobulin E
MH  - Listeriosis/complications/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Ovalbumin/*immunology
MH  - Respiratory Hypersensitivity/complications/*immunology
MH  - Spleen/cytology/immunology
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
PMC - PMC98097
EDAT- 2001/02/17 11:00
MHDA- 2001/05/26 10:01
PMCR- 2001/03/01
CRDT- 2001/02/17 11:00
PHST- 2001/02/17 11:00 [pubmed]
PHST- 2001/05/26 10:01 [medline]
PHST- 2001/02/17 11:00 [entrez]
PHST- 2001/03/01 00:00 [pmc-release]
AID - 0947 [pii]
AID - 10.1128/IAI.69.3.1883-1888.2001 [doi]
PST - ppublish
SO  - Infect Immun. 2001 Mar;69(3):1883-8. doi: 10.1128/IAI.69.3.1883-1888.2001.