PMID- 11180500
OWN - NLM
STAT- MEDLINE
DCOM- 20010419
LR  - 20131121
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 39
IP  - 2
DP  - 2001 Feb
TI  - Anatomic basis of sequence-dependent predictability exhibited by nigral dopamine 
      neuron firing patterns.
PG  - 133-8
AB  - Interspike intervals (ISIs) of dopamine (DA) neurons recorded in the substantia 
      nigra are predicted partially by their immediate prior history. This study was 
      designed to assess neuroanatomic origins of these sequential relationships. ISI 
      data recorded from three groups of nigral DA neurons were studied: 1) 16 neurons 
      recorded in unlesioned animals, 2) 14 neurons recorded after forebrain 
      hemisection, 3) 12 neurons recorded after partial forebrain hemisection that 
      reproduced nonspecific effects of the surgical lesion while leaving forebrain 
      connections intact. As predicted, DA neurons recorded after full forebrain 
      hemisection yielded statistically significant reductions in sequential 
      predictability relative to control neurons and neurons recorded following partial 
      hemisection. These data support the hypothesis that the sequence-dependent 
      behavior of DA neurons arise in part from interactions with forebrain structures. 
      ISI sequences recorded from unlesioned rats demonstrated maximum predictability 
      when an average of 3.7 prior events were incorporated into the forecasting 
      algorithm, thereby suggesting a physiological process whose "depth" of 
      history-dependence is approximately 600-800 msec. Additional studies examining 
      the functional significance of sequence-dependent ISI structure exhibited by 
      nigral DA neurons are indicated.
FAU - Hoffman, R E
AU  - Hoffman RE
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, 
      Connecticut 06520-8099, USA.
FAU - Shi, W X
AU  - Shi WX
FAU - Bunney, B S
AU  - Bunney BS
LA  - eng
GR  - MH52686/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Action Potentials/*physiology
MH  - Algorithms
MH  - Animals
MH  - Denervation/adverse effects
MH  - Dopamine/*metabolism
MH  - Male
MH  - Models, Neurological
MH  - Neural Pathways/cytology/metabolism/surgery
MH  - Neurons/cytology/*metabolism
MH  - Predictive Value of Tests
MH  - Prosencephalon/cytology/metabolism/surgery
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Substantia Nigra/cytology/*metabolism
MH  - Time Factors
EDAT- 2001/02/17 11:00
MHDA- 2001/04/21 10:01
CRDT- 2001/02/17 11:00
PHST- 2001/02/17 11:00 [pubmed]
PHST- 2001/04/21 10:01 [medline]
PHST- 2001/02/17 11:00 [entrez]
AID - 10.1002/1098-2396(200102)39:2<133::AID-SYN4>3.0.CO;2-K [pii]
AID - 10.1002/1098-2396(200102)39:2<133::AID-SYN4>3.0.CO;2-K [doi]
PST - ppublish
SO  - Synapse. 2001 Feb;39(2):133-8. doi: 
      10.1002/1098-2396(200102)39:2<133::AID-SYN4>3.0.CO;2-K.