PMID- 11182024
OWN - NLM
STAT- MEDLINE
DCOM- 20010419
LR  - 20131121
IS  - 0049-0172 (Print)
IS  - 0049-0172 (Linking)
VI  - 30
IP  - 4
DP  - 2001 Feb
TI  - Arthritis related to ileal pouchitis following total proctocolectomy for 
      ulcerative colitis.
PG  - 242-8
AB  - OBJECTIVE: To draw attention to arthritis that developed in patients who 
      underwent total proctocolectomy with ileal pouch construction for ulcerative 
      colitis (UC). METHODS: The course of 4 patients who developed arthritis for the 
      first time after ileal-anal pouch anastomosis is described. In addition, the 
      relationship to the chronic inflammation of the pouch-pouchitis-is discussed. 
      RESULTS: The clinical manifestations were very similar to seronegative arthritis 
      affecting mainly the joints of the lower extremities. It was accompanied by 
      enthesopathy (2 patients) and by sacroiliitis (2 patients). All had active 
      pouchitis. The abnormal laboratory test results were nonspecific, indicating 
      chronic inflammation. All 4 patients tested negative for human leukocyte antigen 
      (HLA) B27, and none had other concomitant extraintestinal manifestations. 
      Steroids rapidly improved both the arthritis and pouchitis; however, 
      disease-modifying antirheumatic drugs were required to maintain remission with 
      minimal daily steroids. Flares of the arthritis were always associated with 
      active pouchitis, but the opposite was not necessarily true. CONCLUSIONS: 
      Arthritis related to ileal pouchitis after total colectomy for UC has many 
      similarities to the arthritis associated with inflammatory bowel disease and 
      should be added to the list of enteropathic arthropathies.
FAU - Balbir-Gurman, A
AU  - Balbir-Gurman A
AD  - B. Shine Department of Rheumatology, Rambam Medical Center, and the Bruce 
      Rappaport Faculty of Medicine, Technion, Haifa, Israel.
FAU - Schapira, D
AU  - Schapira D
FAU - Nahir, M
AU  - Nahir M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Semin Arthritis Rheum
JT  - Seminars in arthritis and rheumatism
JID - 1306053
RN  - 0 (Anti-Bacterial Agents)
RN  - 140QMO216E (Metronidazole)
SB  - IM
CIN - Semin Arthritis Rheum. 2002 Dec;32(3):204-5. PMID: 12528085
CIN - Semin Arthritis Rheum. 2003 Dec;33(3):215. PMID: 14723216
MH  - Adult
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Arthritis, Reactive/*etiology/pathology
MH  - Colitis, Ulcerative/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Metronidazole/therapeutic use
MH  - Middle Aged
MH  - Pouchitis/*etiology/pathology
MH  - Proctocolectomy, Restorative/*adverse effects
EDAT- 2001/02/22 11:00
MHDA- 2001/04/21 10:01
CRDT- 2001/02/22 11:00
PHST- 2001/02/22 11:00 [pubmed]
PHST- 2001/04/21 10:01 [medline]
PHST- 2001/02/22 11:00 [entrez]
AID - S0049-0172(01)47245-3 [pii]
AID - 10.1053/sarh.2001.19960 [doi]
PST - ppublish
SO  - Semin Arthritis Rheum. 2001 Feb;30(4):242-8. doi: 10.1053/sarh.2001.19960.