PMID- 11182193
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20190816
IS  - 0167-5273 (Print)
IS  - 0167-5273 (Linking)
VI  - 77
IP  - 2-3
DP  - 2001 Feb
TI  - Heart rate variability in hypertrophic obstructive cardiomyopathy: association 
      with functional classification and left ventricular outflow gradients.
PG  - 281-6
AB  - BACKGROUND: The aim of this study was to investigate cardiac autonomic control in 
      patients with hypertrophic obstructive cardiomyopathy (HOCM) and to assess the 
      indexes of heart rate variability (HRV) in relation to the clinical and 
      echocardiographic features. METHODS AND RESULTS: Twenty-three patients (17 male, 
      six female: mean age 43+/-11) with HOCM and 18 healthy volunteers were included. 
      M-mode and two-dimensional echocardiography, pulsed and continuous-wave Doppler 
      studies were obtained. All patients and volunteers underwent continuous 24-h 
      ambulatory ECG monitoring. Time domain variables considered in this study were 
      standard deviation of mean R-R intervals (SDNN), root mean-squared successive 
      difference (RMSSD) and percentage of cycles differing from the preceding one by 
      more than 50 ms (PNN 50%). Patients were compared to detect associations between 
      indices of heart rate variability, left ventricular outflow tract obstruction and 
      clinical status. Heart rate variability parameters were also correlated with the 
      echocardiographic and clinical characteristics of the patients. Both New York 
      Heart Association (NYHA) functional class I-II patients (group I) and NYHA III-IV 
      patients (group II) had lower values of SDNN, RMSSD and PNN 50% when compared 
      with the control group (P<0.001, P<0.05 and P<0.01, respectively, for group I and 
      P<0.001, P<0.001 and P<0.001, respectively, for group II). Time domain heart rate 
      variability parameters were found to be significantly correlated with the 
      subaortic dynamic obstruction. CONCLUSION: Heart rate variability is reduced in 
      HOCM and well correlated with the degree of subaortic obstruction. Heart rate 
      variability indices are also sensitive markers of the functional status.
FAU - Doven, O
AU  - Doven O
AD  - Cardiology Department, Ankara University Faculty of Medicine, Ankara, Turkey. 
      odoven@superonline.com
FAU - Sayin, T
AU  - Sayin T
FAU - Guldal, M
AU  - Guldal M
FAU - Karaoguz, R
AU  - Karaoguz R
FAU - Oral, D
AU  - Oral D
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Adult
MH  - Autonomic Nervous System/*physiopathology
MH  - Cardiomyopathy, Hypertrophic/*physiopathology
MH  - Female
MH  - *Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Ventricular Function, Left
EDAT- 2001/02/22 11:00
MHDA- 2001/07/13 10:01
CRDT- 2001/02/22 11:00
PHST- 2001/02/22 11:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/02/22 11:00 [entrez]
AID - S0167-5273(00)00447-2 [pii]
AID - 10.1016/s0167-5273(00)00447-2 [doi]
PST - ppublish
SO  - Int J Cardiol. 2001 Feb;77(2-3):281-6. doi: 10.1016/s0167-5273(00)00447-2.