PMID- 11182228
OWN - NLM
STAT- MEDLINE
DCOM- 20010816
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 62
IP  - 2
DP  - 2001 Feb
TI  - HLA class I diversity in Kolla Amerindians.
PG  - 170-9
AB  - Human leukocyte antigen (HLA) class I polymorphism was studied within a 
      population of 70 unrelated Kolla Amerindians from the far northwest of Argentina 
      close to the Bolivian border. The results indicate that the HLA-A, -B, and -C 
      alleles typical of other Amerindian populations also predominate in the Kolla. 
      These alleles belong to the following allele groups: HLA-A*02, *68, *31, *24, 
      HLA-B*35, *15, *51, *39, *40, *48, and Cw*01, *03, *04, *07, *08, and *15. For 
      the HLA-A locus, heterogeneity was seen for HLA-A*02 with A*0201, *0211, and 
      *0222; and for A*68 with *68012 and *6817, the latter being a novel allele 
      identified in this population. Analysis of HLA-B identified heterogeneity for all 
      Amerindian allele groups except HLA-B*48, including the identification of the 
      novel B*5113 allele. For HLA-C heterogeneity was identified within the Cw*07, 
      *04, and *08 groups with Cw*0701/06, *0702, *04011, *0404, *0803, and *0809 
      identified. The most frequent "probable" haplotype found in this population was 
      B*3505-Cw*04011. This study supports previous studies, which demonstrate 
      increased diversity at HLA-B compared with HLA-A and -C. The polymorphism 
      identified within the Kolla HLA-A, -B, and -C alleles supports the hypothesis 
      that HLA evolution is subject to positive selection for diversity within the 
      peptide binding site.
FAU - Little, A M
AU  - Little AM
AD  - Anthony Nolan Research Institute, The Royal Free Hospital, London, United 
      Kingdom.
FAU - Scott, I
AU  - Scott I
FAU - Pesoa, S
AU  - Pesoa S
FAU - Marsh, S G
AU  - Marsh SG
FAU - Arguello, R
AU  - Arguello R
FAU - Cox, S T
AU  - Cox ST
FAU - Ramon, D
AU  - Ramon D
FAU - Vullo, C
AU  - Vullo C
FAU - Madrigal, J A
AU  - Madrigal JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
MH  - Alleles
MH  - Argentina
MH  - Female
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - Haplotypes/immunology
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Testing/methods/standards
MH  - Humans
MH  - Indians, South American/*genetics
MH  - Male
MH  - Nucleic Acid Conformation
MH  - Oligonucleotide Probes/genetics
MH  - Polymerase Chain Reaction/methods
MH  - Polymorphism, Genetic/immunology
MH  - Reference Values
MH  - Sequence Analysis, DNA
EDAT- 2001/02/22 11:00
MHDA- 2001/08/21 10:01
CRDT- 2001/02/22 11:00
PHST- 2001/02/22 11:00 [pubmed]
PHST- 2001/08/21 10:01 [medline]
PHST- 2001/02/22 11:00 [entrez]
AID - S0198-8859(00)00248-2 [pii]
AID - 10.1016/s0198-8859(00)00248-2 [doi]
PST - ppublish
SO  - Hum Immunol. 2001 Feb;62(2):170-9. doi: 10.1016/s0198-8859(00)00248-2.