PMID- 11186302
OWN - NLM
STAT- MEDLINE
DCOM- 20010503
LR  - 20220228
IS  - 0962-8436 (Print)
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Linking)
VI  - 355
IP  - 1400
DP  - 2000 Aug 29
TI  - Is human T-cell lymphotropic virus type I really silent?
PG  - 1013-9
AB  - The role of the cellular immune response to human T-cell lymphotropic virus type 
      I (HTLV-I) is not fully understood. The low level of HTLV-I protein expression in 
      peripheral blood lymphocytes has led to the widely held belief that HTLV-I is 
      transcriptionally silent in vivo. However, most HTLV-I-infected individuals mount 
      a strong and persistently activated cytotoxic T-lymphocyte (CTL) response to the 
      virus; this observation implies that there is abundant chronic transcription of 
      HTLV-I genes. Here we show that HTLV-I Tax protein expression rises quickly in 
      freshly isolated peripheral blood lymphocytes, but that expressing cells are 
      rapidly killed by CTLs. Mathematical analysis of these results indicates that the 
      CTL response is extremely efficient and that the half-life of a Tax-expressing 
      cell is less than a day. We propose that HTLV-I protein expression in circulating 
      lymphocytes is undetectable by current techniques because of the efficiency of 
      the CTL-mediated immune surveillance in vivo.
FAU - Asquith, B
AU  - Asquith B
AD  - Department of Immunology, Imperial College School of Medicine, London, UK. 
      r.asquith@ic.ac.uk
FAU - Hanon, E
AU  - Hanon E
FAU - Taylor, G P
AU  - Taylor GP
FAU - Bangham, C R
AU  - Bangham CR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological 
      sciences
JID - 7503623
SB  - IM
MH  - *HTLV-I Infections/immunology/virology
MH  - Human T-lymphotropic virus 1/immunology/*physiology
MH  - Humans
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - *Virus Latency
PMC - PMC1692812
EDAT- 2001/02/24 12:00
MHDA- 2001/05/05 10:01
PMCR- 2002/08/29
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/05/05 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
PHST- 2002/08/29 00:00 [pmc-release]
AID - 10.1098/rstb.2000.0638 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2000 Aug 29;355(1400):1013-9. doi: 
      10.1098/rstb.2000.0638.