PMID- 11191641
OWN - NLM
STAT- MEDLINE
DCOM- 20010201
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 68
IP  - 3
DP  - 2000 Dec 8
TI  - Structure and function of Toll-like receptor proteins.
PG  - 241-58
AB  - Beginning in 1997 with the identification of the first human homologue of the 
      Drosophila protein Toll, a family of related molecules have been identified in 
      both humans and other mammals. These Toll-like receptor (TLR) proteins appear to 
      represent a conserved family of innate immune recognition receptors. TLR proteins 
      share extended homology with receptors for the cytokines interleukin 1 (IL-1) and 
      interleukin 18 (IL-18). These receptors are coupled to a signaling pathway that 
      is conserved in mammals, insects, and plants, resulting in cellular activation, 
      thereby stimulating innate immune defenses. A variety of bacterial and fungal 
      products have been identified that serve as TLR ligands, and more recent studies 
      have identified the first endogenous protein ligands for TLR proteins. While TLR 
      signaling is likely to be a key feature of innate immune responses, these 
      proteins may also regulate homeostasis via interaction with endogenous protein 
      ligands.
FAU - Means, T K
AU  - Means TK
AD  - The Pulmonary Center, Boston University School of Medicine, Boston Medical 
      Center, MA 02118, USA.
FAU - Golenbock, D T
AU  - Golenbock DT
FAU - Fenton, M J
AU  - Fenton MJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Drosophila Proteins)
RN  - 0 (IL18R1 protein, human)
RN  - 0 (Il18r1 protein, mouse)
RN  - 0 (Interleukin-18 Receptor alpha Subunit)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Receptors, Interleukin-18)
RN  - 0 (Toll-Like Receptor 5)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (tehao protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Drosophila
MH  - *Drosophila Proteins
MH  - Humans
MH  - Interleukin-18 Receptor alpha Subunit
MH  - Membrane Glycoproteins/*chemistry/*physiology
MH  - Mice
MH  - Molecular Sequence Data
MH  - Receptors, Cell Surface/*chemistry/*physiology
MH  - Receptors, Interleukin/chemistry/physiology
MH  - Receptors, Interleukin-1/chemistry/physiology
MH  - Receptors, Interleukin-18
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Toll-Like Receptor 5
MH  - Toll-Like Receptors
RF  - 86
EDAT- 2001/02/24 12:00
MHDA- 2001/02/28 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - S0024320500009395 [pii]
AID - 10.1016/s0024-3205(00)00939-5 [doi]
PST - ppublish
SO  - Life Sci. 2000 Dec 8;68(3):241-58. doi: 10.1016/s0024-3205(00)00939-5.