PMID- 11191795
OWN - NLM
STAT- MEDLINE
DCOM- 20010405
LR  - 20081121
IS  - 0028-2162 (Print)
IS  - 0028-2162 (Linking)
VI  - 144
IP  - 53
DP  - 2000 Dec 30
TI  - [Vancomycin-resistant Enterococcus faecium outbreak in a nephrology ward].
PG  - 2568-72
AB  - In April 2000, an outbreak of vancomycin-resistant Enterococcus faecium (VRE) was 
      discovered in an internal medicine/nephrology and dialysis ward of the Eemland 
      Hospital, Amersfoort, the Netherlands. Although enterococci are considered 
      relatively non-virulent, VRE are resistant to almost all commercially available 
      antibiotics. Surveillance cultures were obtained from all patients at the ward, 
      all patients visiting the dialysis ward and the environment of patients. VRE were 
      determined and clustering of strains was analysed using molecular genotyping. In 
      all, 12 patients were colonized with the outbreak strain. Transmission of VRE 
      usually occurs via the hands of health care workers. The ward was closed for new 
      admissions, patients were divided in cohorts of colonized and non-colonized 
      patients, and rooms were disinfected after patient discharge. Infection control 
      measures (such as handwashing and use of gloves and gowns) were enforced and 
      prescriptions of vancomycin and cephalosporins were reduced. With these measures 
      the outbreak could be controlled. Epidemiological analysis demonstrated that 
      earlier admission and previous use of ciprofloxacin, amoxicillin and 
      amoxicillin-clavulanic acid were risk factors for colonization. A nearby hospital 
      was a possible source of this outbreak.
FAU - van der Steen, L F
AU  - van der Steen LF
AD  - Universitair Medisch Centrum Utrecht, divisie Interne Geneeskunde, afd. 
      Infectieziekten & Aids, Heidelberglaan 100, 3584 CX Utrecht.
FAU - Bonten, M J
AU  - Bonten MJ
FAU - van Kregten, E
AU  - van Kregten E
FAU - Harssema-Poot, J J
AU  - Harssema-Poot JJ
FAU - Willems, R
AU  - Willems R
FAU - Gaillard, C A
AU  - Gaillard CA
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - Uitbraak van vancomycineresistente Enterococcus faecium op een afdeling 
      Nefrologie.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
CIN - Ned Tijdschr Geneeskd. 2000 Dec 30;144(53):2572-6. PMID: 11191796
MH  - Aged
MH  - Disease Outbreaks/prevention & control/*statistics & numerical data
MH  - Enterococcus faecium/isolation & purification/*pathogenicity
MH  - Female
MH  - Genotype
MH  - Gram-Positive Bacterial Infections/*epidemiology/microbiology/*transmission
MH  - Hemodialysis Units, Hospital/*statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Infection Control/*methods
MH  - Infectious Disease Transmission, Professional-to-Patient/statistics & numerical 
      data
MH  - Male
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Risk Factors
MH  - *Vancomycin Resistance
EDAT- 2001/02/24 12:00
MHDA- 2001/04/06 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/04/06 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2000 Dec 30;144(53):2568-72.