PMID- 11192527
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20220311
IS  - 1328-8067 (Print)
IS  - 1328-8067 (Linking)
VI  - 42
IP  - 6
DP  - 2000 Dec
TI  - Pattern of human leukocyte antigens in Turkish children with celiac disease.
PG  - 678-81
AB  - BACKGROUND: Regional variations in the human leukocyte antigen (HLA) distribution 
      patterns of celiac disease (CD) have been reported. The aim of the present study 
      was to assess the distribution of HLA class I and class II in Turkish children 
      with CD and to compare the findings with a control group. METHODS: Human 
      leukocyte antigen typing was performed in 33 children with CD and in 77 healthy 
      individuals, who served as controls, by using standard National Institutes of 
      Health lymphocytotoxicity techniques. RESULTS: A positive association was found 
      between HLA A2 (42 vs 19% for sick subjects compared with healthy controls, 
      respectively), B8 (39 vs. 9% for sick subjects compared with healthy controls, 
      respectively), CW7 (45 vs. 25% for sick subjects compared with healthy controls, 
      respectively), DR3 (70 vs. 17% for sick subjects compared with healthy controls, 
      respectively), DR7 (30 vs. 13% for sick subjects compared with healthy controls, 
      respectively) and DQ2 (52 vs. 34% for sick subjects compared with healthy 
      controls, respectively). The combinations of DR3-DQ2 (30 vs. 12% for sick 
      subjects compared with healthy controls, respectively), DR3-DR4 (21 vs. 1% for 
      sick subjects compared with healthy controls, respectively) and DR7-DQ2 (21 vs. 
      6% for sick subjects compared with healthy controls, respectively) were also 
      found to be significantly important in children with CD. The highest relative 
      risk (RR) was for HLA B8 in class I (RR 6.50), for DR3 (RR 11.30) in class II and 
      for combination of DR3-DR4 (RR 20.46). The highest etiologic fraction (EF) was 
      for the DR3 antigen (EF 0.55). CONCLUSIONS: The present study emphasizes that HLA 
      genotypes are an important background to CD development, but some additional 
      susceptibility factors remain to be identified.
FAU - Tumer, L
AU  - Tumer L
AD  - Department of Pediatrics, Gazi University, Gazi Hospital, Ankara, Turkey. 
      tumerleyla@hotmail.com
FAU - Altuntas, B
AU  - Altuntas B
FAU - Hasanoglu, A
AU  - Hasanoglu A
FAU - Soylemezoglu, O
AU  - Soylemezoglu O
FAU - Arinsoy, T
AU  - Arinsoy T
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (HLA-B8 Antigen)
SB  - IM
MH  - Celiac Disease/*immunology
MH  - Child
MH  - Genes, MHC Class I
MH  - HLA Antigens/genetics/*immunology
MH  - HLA-A2 Antigen/analysis
MH  - HLA-B8 Antigen/analysis
MH  - Histocompatibility Testing
MH  - Humans
MH  - Risk Factors
MH  - Turkey
EDAT- 2001/02/24 12:00
MHDA- 2001/05/01 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1046/j.1442-200x.2000.01311.x [doi]
PST - ppublish
SO  - Pediatr Int. 2000 Dec;42(6):678-81. doi: 10.1046/j.1442-200x.2000.01311.x.