PMID- 11194937
OWN - NLM
STAT- MEDLINE
DCOM- 20010322
LR  - 20190812
IS  - 0001-6322 (Print)
IS  - 0001-6322 (Linking)
VI  - 101
IP  - 1
DP  - 2001 Jan
TI  - Prenatal exposure to ethanol induces leptomeningeal heterotopia in the cerebral 
      cortex of the rat fetus.
PG  - 22-6
AB  - Pregnant rats were fed an ethanol-containing liquid diet between gestational day 
      (GD) 10 and GD 21. Leptomeningeal heterotopias were observed in the cerebral 
      cortex of ethanol-exposed fetuses. They appeared on the brain surface of the 
      lateral cortical region near the rhinal fissure, and were found more numerously 
      in the rostral than the caudal region. These abnormalities contained certain 
      neuronal perikarya, microtubule-associated protein (MAP) 1b-positive neuronal 
      processes, and Rat-401-positive radial glial fibers. Immunostaining for Rat-401 
      revealed that the heterotopias protruded through breaches in the glia limitans. 
      In adult rats exposed to ethanol prenatally, the heterotopias persisted in the 
      lateral cortical region. We conclude that prenatal exposure to ethanol might 
      induce defects in the glia limitans, resulting in the genesis of leptomeningeal 
      heterotopias. These abnormalities may be related to mental retardation or the 
      cognitive deficits associated with human fetal alcohol syndrome (FAS).
FAU - Komatsu, S
AU  - Komatsu S
AD  - Department of Anatomy, University of Tokushima School of Medicine, Japan.
FAU - Sakata-Haga, H
AU  - Sakata-Haga H
FAU - Sawada, K
AU  - Sawada K
FAU - Hisano, S
AU  - Hisano S
FAU - Fukui, Y
AU  - Fukui Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Acta Neuropathol
JT  - Acta neuropathologica
JID - 0412041
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcohol-Induced Disorders, Nervous System/*pathology/physiopathology
MH  - Animals
MH  - Cell Movement/drug effects/physiology
MH  - Cerebral Cortex/*drug effects/*pathology
MH  - Ethanol/*pharmacology
MH  - Female
MH  - Pia Mater/drug effects/pathology
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
EDAT- 2001/02/24 12:00
MHDA- 2001/03/27 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/27 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1007/s004010000257 [doi]
PST - ppublish
SO  - Acta Neuropathol. 2001 Jan;101(1):22-6. doi: 10.1007/s004010000257.