PMID- 11195261
OWN - NLM
STAT- MEDLINE
DCOM- 20010405
LR  - 20191025
IS  - 0268-1315 (Print)
IS  - 0268-1315 (Linking)
VI  - 16
IP  - 1
DP  - 2001 Jan
TI  - Olanzapine-induced leukopenia with human leukocyte antigen profiling.
PG  - 55-7
AB  - Olanzapine is an atypical antipsychotic medication frequently used in the 
      management of psychotic states. While it has proved to be safe compared to 
      clozapine with regard to haematotoxicity, because it has only been available for 
      a few years, full documentation of its haematological side-effects remains 
      incomplete. We report a case of olanzapine-induced leukopenia with associated 
      neutropenia. Since clozapine-induced haematotoxicity has been associated with 
      characteristic human leukocyte antigen (HLA) groups, HLA typing was determined in 
      this patient. Following failure with typical antipsychotic medication, the 
      patient received 10 mg/day of olanzapine. Three weeks later, he developed fever 
      and a significant decrease in leukocyte count. Olanzapine was immediately 
      discontinued. HLA typing was determined. The white cell count returned to normal 
      and the fever, most probably secondary to the low white cell count, subsided with 
      antibiotic treatment. HLA typing results were: A1 24, B7, B35, DRB1*15, DRB1*11, 
      DRB3*01-03, DRB5*01-02. Olanzapine may induce serious leukopenia and neutropenia. 
      HLA typing in this single patient demonstrated a distinct haplotype compared to 
      that previously observed in clozapine-induced haematoxicity.
FAU - Buchman, N
AU  - Buchman N
AD  - Beer Yaakov Mental Health Center, Sackler School of Medicine, Tel-Aviv 
      University, Beer Sheba, Israel.
FAU - Strous, R D
AU  - Strous RD
FAU - Ulman, A M
AU  - Ulman AM
FAU - Lerner, M
AU  - Lerner M
FAU - Kotler, M
AU  - Kotler M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int Clin Psychopharmacol
JT  - International clinical psychopharmacology
JID - 8609061
RN  - J60AR2IKIC (Clozapine)
SB  - IM
MH  - Clozapine/*adverse effects/therapeutic use
MH  - Haplotypes
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Leukocyte Count
MH  - Leukopenia/*chemically induced/genetics
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Schizophrenia/*drug therapy/immunology
EDAT- 2001/02/24 12:00
MHDA- 2001/04/06 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/04/06 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1097/00004850-200101000-00007 [doi]
PST - ppublish
SO  - Int Clin Psychopharmacol. 2001 Jan;16(1):55-7. doi: 
      10.1097/00004850-200101000-00007.