PMID- 11195644
OWN - NLM
STAT- MEDLINE
DCOM- 20010308
LR  - 20131121
IS  - 0005-2086 (Print)
IS  - 0005-2086 (Linking)
VI  - 44
IP  - 4
DP  - 2000 Oct-Dec
TI  - Alterations in levels of various host antioxidant factors in turkey knockdown 
      syndrome.
PG  - 891-5
AB  - Five components (selenium, glutathione peroxidase, copper, superoxide dismutase, 
      and vitamin E) of the antioxidant system of turkey poults were examined to 
      determine if they play any role in the knockdown (KD) syndrome. All flocks were 
      provided with feed formulated to contain monensin at 54-60 g/ton. Flock data were 
      analyzed as a case-control study with three treatment groups (KD-affected and 
      unaffected turkey poults from a KD flock and poults from an unaffected flock 
      [control]). Affected turkey poults had lower (P < 0.001) serum vitamin E levels 
      compared with unaffected poults from KD flocks or poults from unaffected flocks. 
      No significant differences were observed for the other parameters evaluated but 
      there was a trend towards lower copper and superoxide dismutase values in 
      affected birds. It appears that serum vitamin E concentrations in turkey poults 
      may play a significant role in susceptibility to or protection against KD 
      syndrome. Other components of the antioxidant system may also be involved, and 
      complex interactions among several body systems may be critical.
FAU - Meldrum, J B
AU  - Meldrum JB
AD  - Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, 
      Blacksburg 24061, USA.
FAU - Evans, R D
AU  - Evans RD
FAU - Robertson, J L
AU  - Robertson JL
FAU - Watkins, K L
AU  - Watkins KL
FAU - Novilla, M N
AU  - Novilla MN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Avian Dis
JT  - Avian diseases
JID - 0370617
RN  - 0 (Antioxidants)
RN  - 1406-18-4 (Vitamin E)
RN  - 789U1901C5 (Copper)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Copper/blood
MH  - Disease Susceptibility
MH  - Glutathione Peroxidase/blood
MH  - Lameness, Animal/blood
MH  - Poultry Diseases/*blood
MH  - Selenium/blood
MH  - Superoxide Dismutase/blood
MH  - Syndrome
MH  - Turkeys/*blood
MH  - Vitamin E/blood
EDAT- 2001/02/24 12:00
MHDA- 2001/03/10 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/10 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
PST - ppublish
SO  - Avian Dis. 2000 Oct-Dec;44(4):891-5.