PMID- 11196541
OWN - NLM
STAT- MEDLINE
DCOM- 20010301
LR  - 20220408
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 28
IP  - 1
DP  - 2001 Jan
TI  - Plasma monocyte chemoattractant protein 1 is a marker for joint inflammation in 
      rheumatoid arthritis.
PG  - 41-6
AB  - OBJECTIVE: Monocyte chemoattractant protein 1 (MCP-1) level in plasma is 
      described as a marker for joint inflammation in rheumatoid arthritis (RA). 
      METHODS: MCP-1 in plasma and synovial fluid (SF) was quantified by ELISA in 36 RA 
      patients with synovitis of the knee at Day 1 and 30. Disease activity was 
      assessed by the swollen joint count, Ritchie Articular Index (RAI), global 
      assessment, pain on visual analog scale, Health Assessment Questionnaire, 
      erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). RESULTS: By 
      linear regression analysis plasma MCP-1 levels correlated significantly with the 
      swollen joint count (Day 1: R = 0.47, p = 0.005; Day 30: R = 0.53, p < 0.001) and 
      the RAI (Day 1: R = 0.37, p = 0.03; Day 30: R = 0.41, p = 0.01). The correlations 
      of swollen joint count and RAI with ESR and CRP were significant only on Day 30 
      for the ESR (R = 0.40, p = 0.02). No association was found between plasma MCP-1 
      levels and the ESR/CRP levels. MCP-1 levels in plasma in RA patients were 
      elevated compared to controls (p < 0.001) and MCP-I levels in SF were higher than 
      in plasma (p < 0.001). No correlation was found between SF MCP-1 levels and in 
      vitro migration of mononuclear cells towards SF. MCP-1 appears to participate in 
      the disease process in RA, and plasma MCP-1 may be useful in monitoring joint 
      inflammation.
FAU - Ellingsen, T
AU  - Ellingsen T
AD  - Department of Rheumatology, Arhus University Hospital, Denmark.
FAU - Buus, A
AU  - Buus A
FAU - Stengaard-Pedersen, K
AU  - Stengaard-Pedersen K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*blood/complications/pathology
MH  - Biomarkers/analysis
MH  - Blood Sedimentation
MH  - C-Reactive Protein/analysis
MH  - Chemokine CCL2/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Knee Joint/*pathology/physiopathology
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Synovial Fluid/metabolism
MH  - Synovitis/*blood/etiology/pathology
EDAT- 2001/02/24 12:00
MHDA- 2001/03/07 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/07 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 2001 Jan;28(1):41-6.