PMID- 11196708
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20081121
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 1
IP  - 4
DP  - 2000
TI  - A new polymorphism in the promoter region of the human interleukin-16 (IL-16) 
      gene.
PG  - 293-4
AB  - Interleukin 16 (IL-16) is a chemotactic cytokine which binds to CD4 and affects T 
      cell activation. Here we report a novel single nucleotide polymorphism, T to C, 
      in the promoter region of the IL-16 gene in two distinct Asian populations, 
      Japanese and Thai. This mutation occurs at an allele frequency of approximately 
      22% and 18%, respectively. Although IL-16 potently suppresses replication of 
      human immunodeficiency virus type 1 (HIV-1), we observed no significant 
      difference in the allele frequency of this polymorphism between HIV-1-infected 
      and non-HIV-1-infected individuals in both Asian populations. Since differential 
      IL-16 levels have been reported to be associated with inflammatory diseases such 
      as systemic lupus erythematosus, atopic dermatitis and allergic asthma, it would 
      be of interest to analyze the allele frequency of this mutation in patients with 
      these autoimmune and allergic diseases.
FAU - Nakayama, E E
AU  - Nakayama EE
AD  - Department of Infectious Diseases, Institute of Medical Science, University of 
      Tokyo, Tokyo, Japan.
FAU - Wasi, C
AU  - Wasi C
FAU - Ajisawa, A
AU  - Ajisawa A
FAU - Iwamoto, A
AU  - Iwamoto A
FAU - Shioda, T
AU  - Shioda T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (Interleukin-16)
SB  - IM
MH  - Gene Frequency
MH  - HIV Infections/genetics
MH  - Humans
MH  - Interleukin-16/*genetics
MH  - Japan
MH  - Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Thailand
EDAT- 2001/02/24 12:00
MHDA- 2001/03/03 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1038/sj.gene.6363672 [doi]
PST - ppublish
SO  - Genes Immun. 2000;1(4):293-4. doi: 10.1038/sj.gene.6363672.