PMID- 11197624
OWN - NLM
STAT- MEDLINE
DCOM- 20010322
LR  - 20191025
IS  - 0937-9827 (Print)
IS  - 0937-9827 (Linking)
VI  - 114
IP  - 1-2
DP  - 2000
TI  - Is vitreous humour useful for the interpretation of 
      3,4-methylenedioxymethamphetamine (MDMA) blood levels? Experimental approach with 
      rabbits.
PG  - 29-35
AB  - As drug instability and redistribution are factors known to affect the 
      interpretation of post-mortem blood levels, we questioned whether post-mortem 
      vitreous humour concentrations could be useful as predictors for the MDMA load at 
      the time of death. In a first series of in vivo experiments using rabbits, 
      3,4-methylenedioxymethamphetamine (MDMA) concentrations in plasma, blood and 
      vitreous humour were studied as a function of time after intravenous (i.v.) 
      administration of MDMA. Equilibration between the vascular compartment and 
      vitreous humour was attained about 1 h after i.v. MDMA administration. In a 
      second series of experiments, the post-mortem stability of MDMA in vitreous 
      humour in relation to ambient temperature was investigated. Post-mortem MDMA 
      concentrations in vitreous humour were closer to the ante-mortem blood levels 
      when compared to cardiac blood samples. These preliminary investigations in the 
      rabbit model indicate that measurements of vitreous humour concentrations could 
      also be of interest for predicting the blood concentration at the time of death 
      in humans.
FAU - De Letter, E A
AU  - De Letter EA
AD  - Department of Forensic Medicine, Ghent University, J. Kluyskensstraat 29, 9000 
      Ghent, Belgium.
FAU - De Paepe, P
AU  - De Paepe P
FAU - Clauwaert, K M
AU  - Clauwaert KM
FAU - Belpaire, F M
AU  - Belpaire FM
FAU - Lambert, W E
AU  - Lambert WE
FAU - Van Bocxlaer, J F
AU  - Van Bocxlaer JF
FAU - Piette, M H
AU  - Piette MH
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Int J Legal Med
JT  - International journal of legal medicine
JID - 9101456
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Aqueous Humor/*chemistry
MH  - Autopsy/*methods
MH  - Female
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis/*blood/pharmacokinetics
MH  - Postmortem Changes
MH  - Rabbits
MH  - Statistics, Nonparametric
MH  - Temperature
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 2001/02/24 12:00
MHDA- 2001/03/27 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/27 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1007/s004140000135 [doi]
PST - ppublish
SO  - Int J Legal Med. 2000;114(1-2):29-35. doi: 10.1007/s004140000135.