PMID- 11198379
OWN - NLM
STAT- MEDLINE
DCOM- 20010621
LR  - 20130502
IS  - 1110-0583 (Print)
IS  - 1110-0583 (Linking)
VI  - 30
IP  - 3
DP  - 2000 Dec
TI  - Sublethal concentration of Ambrosia maritima(Damsissa) affecting compatibility of 
      Biomphalaria alexandrina snails to infection with Schistosoma mansoni through 
      disturbing the glycolytic pathway.
PG  - 809-19
AB  - High glycolytic flux as an emergency pathway for generating ATP was recorded as 
      the most important metabolic pathway required for the success of 
      Biomphalaria-Schistosome sporocyst interaction. Effect of LC25 of dry powdered 
      Ambrosia maritima (Damsissa) as plant molluscicide on hexokinase (HK), pyruvate 
      kinase(PK), glucose phosphate isomerase(GPI) was tested. It resulted in a 
      significant inhibition of the three investigated enzymes. Treatment of snails 
      with LC10 concentrations of A. maritima reduced considerably the infection rate 
      of Biomphalaria alexandrina with Schistosoma mansoni to be 34% compared to an 
      infection rate of 80% in control non-treated snails. Longer prepatent period and 
      remarkable decrease in cercarial production was also recorded in snails treated 
      with the sublethal concentrations of this molluscicide.
FAU - el-Ansary, A
AU  - el-Ansary A
AD  - Department of Medicinal Chemistry, National Research Centre, Dokki, Giza, Egypt.
FAU - el-Bardicy, S
AU  - el-Bardicy S
FAU - Soliman, M S
AU  - Soliman MS
FAU - Zayed, N
AU  - Zayed N
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - J Egypt Soc Parasitol
JT  - Journal of the Egyptian Society of Parasitology
JID - 8102141
RN  - 0 (Molluscacides)
RN  - 0 (Plant Extracts)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
RN  - EC 5.4.2.2 (Phosphoglucomutase)
SB  - IM
MH  - Animals
MH  - Asteraceae/*chemistry
MH  - Biomphalaria/*drug effects/*parasitology
MH  - Glycolysis/*drug effects
MH  - Hexokinase/metabolism
MH  - Host-Parasite Interactions/*drug effects
MH  - Molluscacides/administration & dosage/*pharmacology
MH  - Phosphoglucomutase/metabolism
MH  - Plant Extracts/administration & dosage/*pharmacology
MH  - Pyruvate Kinase/metabolism
MH  - Schistosoma mansoni/*drug effects
EDAT- 2001/02/24 12:00
MHDA- 2001/06/22 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/06/22 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
PST - ppublish
SO  - J Egypt Soc Parasitol. 2000 Dec;30(3):809-19.