PMID- 11199114
OWN - NLM
STAT- MEDLINE
DCOM- 20010405
LR  - 20131121
IS  - 0934-8387 (Print)
IS  - 0934-8387 (Linking)
VI  - 54
IP  - 12
DP  - 2000 Dec
TI  - [Correlation of plasma glutathione and total IgE level: evidence for a regulatory 
      role of antipxodants in vivo].
PG  - 569-71
AB  - BACKGROUND: Atopy is characterized by increased levels of circulating 
      immunoglobulin E (IgE). Moreover, elevated IgE levels are frequently observed in 
      HIV-infected individuals and are of prognostic significance in these patients. 
      Several In vitro studies have established an association of intracellular 
      antioxidants like glutathione with IgE production by B-lymphocytes, suggesting a 
      regulatory role of these substances in IgE synthesis. However, in vivo data 
      consistent with these findings have not been reported. METHODS: Total IgE levels, 
      CD4(+)-lymphocyte count and plasma glutathione were determined in non-atopic, 
      HIV-positive individuals. RESULTS: 27 HIV-positive subjects (mean age Alter +/- 
      SD: 43 +/- 11 years, 85% males) were studied. Mean CD4(+)-lymphocyte count was 
      250 +/- 136/microliter. The median serum IgE level was 85.3 U/ml (Range: 3-1298 
      U/ml), and the mean plasma glutathione concentration was 2.08 +/- 0.7 muMol. 
      Plasma glutathione was significantly correlated with CD4(+)-lymphocyte count (r = 
      0.37; p = 0.05), and was inversely related to total IgE (r = -0.46; p = 0.01). 
      CONCLUSIONS: Plasma glutathione and total IgE levels are negatively correlated in 
      HIV-positive individuals. This observation supports the concept of a regulatory 
      role of antioxidants and IgE synthesis in vivo. Further studies aiming at the 
      possible significance of these mechanisms in atopic patients are clearly 
      warranted.
FAU - Beeh, K M
AU  - Beeh KM
AD  - Schwerpunkt Pneumologie, III. Medizinische Klinik, Universitatsklinik Mainz. 
      k.beeh@3-med.klinik.uni-mainz.de
FAU - Micke, P
AU  - Micke P
FAU - Kornmann, O
AU  - Kornmann O
FAU - Buhl, R
AU  - Buhl R
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Korrelation von Plasma-Glutathion und Gesamt-IgE-Spiegeln: Hinweise fur eine 
      regulatorische Rolle von Antioxidantien In vivo.
PL  - Germany
TA  - Pneumologie
JT  - Pneumologie (Stuttgart, Germany)
JID - 8906641
RN  - 0 (Antioxidants)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adult
MH  - Antioxidants/*metabolism
MH  - Female
MH  - Glutathione/*blood
MH  - HIV Infections/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Respiratory Hypersensitivity/immunology
EDAT- 2001/02/24 12:00
MHDA- 2001/04/06 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/04/06 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1055/s-2000-9187 [doi]
PST - ppublish
SO  - Pneumologie. 2000 Dec;54(12):569-71. doi: 10.1055/s-2000-9187.