PMID- 11200064
OWN - NLM
STAT- MEDLINE
DCOM- 20010322
LR  - 20091119
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 69
IP  - 1
DP  - 2001 Jan
TI  - MAP kinase activation in macrophages.
PG  - 3-10
AB  - Stimulation of macrophages by a variety of agents causes activation of 
      mitogen-activated protein kinases (MAPKs). Activation of MAPKs by 
      lipopolysaccharide involves CD14 and Toll receptors. Subsequent steps still 
      remain to be explored. Tumor necrosis factor-alpha (TNF-alpha)-induced activation 
      of MAPKs has been shown to involve the death domain proteins (TRADD, FADD, MADD) 
      and TRAFs. Other molecules involved in this pathway include the protein kinases, 
      ASK1, germinal center kinase (GCK), hematopoietic progenitor kinase 1 (HPK1), and 
      GCK-related kinase (GCKR). Although, these pathways have been described in 
      various cell types, their role in macrophages remains to be established. The 
      availability of knockout mice and constitutively active and dominant-negative 
      mutants of MAPKs should greatly enhance our understanding of this field. The 
      activation of MAPKs seems to be different in cell lines compared with primary 
      cells. Among the macrophages, cells from different compartments show different 
      expression of receptors and signal transduction molecules. These differences may 
      account for differences in MAPK activation and other phenotypic differences in 
      macrophages from different compartments. Therefore, it is important to use 
      primary cells for studying MAPK signal-transduction pathways, and the data from 
      cell lines should not be extrapolated to primary cells.
FAU - Rao, K M
AU  - Rao KM
AD  - Pathology and Physiology Research Branch, Health Effects Laboratory Division, 
      National Institute for Occupational Safety and Health, Morgantown, West Virginia, 
      USA. mir8@cdc.gov
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - MAP Kinase Signaling System
MH  - Macrophage Activation/*physiology
MH  - Macrophages/*physiology
MH  - Mitogen-Activated Protein Kinases/*physiology
MH  - Signal Transduction
RF  - 117
EDAT- 2001/02/24 12:00
MHDA- 2001/03/27 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/27 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
PST - ppublish
SO  - J Leukoc Biol. 2001 Jan;69(1):3-10.