PMID- 11200812
OWN - NLM
STAT- MEDLINE
DCOM- 20010405
LR  - 20190921
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 44
IP  - 6
DP  - 2000 Dec
TI  - Theoretical basis for herbal medicines, Tokishakuyaku-san and Sairei-to, in the 
      treatment of autoimmunity-related recurrent abortion by correcting T helper-1/T 
      helper-2 balance.
PG  - 342-6
AB  - PROBLEM AND METHOD OF STUDY: To get insight into the basis for the empirical 
      usage of herbal medicines in the treatment of recurrent abortion, we examined 
      whether Tokishakuyaku-san (Toki) and Sairei-to (Sai) modulate T helper-1 (Th1) 
      and T helper-2 (Th2) cytokine release from peripheral blood mononuclear cells 
      (PBMCs). The effects of these medicines were investigated as related to human 
      leukocyte antigen (HLA)-G, a non-classical HLA class I antigen expressed on 
      trophoblasts and a putative crucial player involved in fetomaternal immune 
      interplay. RESULTS: Toki and Sai increased the release of Th1 group cytokines, 
      tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma while preserving the 
      inhibitory effect of HLA-G on the release of these cytokines. As for Th2 group 
      cytokine release, Toki was without effect in modulating interleukin (IL)-4 
      release, regardless of the presence of HLA-G, whereas Sai nullified the effect of 
      the presence of HLA-G to stimulate the release of IL-4 without affecting its 
      release in the absence of HLA-G. CONCLUSION: Toki and Sai may have therapeutic 
      potential, particularly in autoimmunity-related recurrent abortion where Th2 
      response is pathologically enhanced, but not in recurrent abortion involving 
      alloimmune fetomaternal derangement, a condition of, rather, an enhanced Thl 
      response.
FAU - Fujii, T
AU  - Fujii T
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, University of 
      Tokyo, Japan. fujiit-tky@umin.ac.jp
FAU - Kanai, T
AU  - Kanai T
FAU - Kozuma, S
AU  - Kozuma S
FAU - Hamai, Y
AU  - Hamai Y
FAU - Hyodo, H
AU  - Hyodo H
FAU - Yamashita, T
AU  - Yamashita T
FAU - Miki, A
AU  - Miki A
FAU - Unno, N
AU  - Unno N
FAU - Taketani, Y
AU  - Taketani Y
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Benzoates)
RN  - 0 (Bridged-Ring Compounds)
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Glucosides)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Monoterpenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (sairei-to)
RN  - 21AIQ4EV64 (peoniflorin)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 3.4.22.36 (Caspase 1)
SB  - IM
MH  - Abortion, Habitual/*therapy
MH  - Adult
MH  - Autoimmunity/*drug effects
MH  - *Benzoates
MH  - *Bridged-Ring Compounds
MH  - Caspase 1/metabolism
MH  - Cytokines/*metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Female
MH  - Glucosides/*pharmacology
MH  - HLA Antigens/pharmacology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/pharmacology
MH  - Humans
MH  - Interferon-gamma/metabolism
MH  - Monoterpenes
MH  - T-Lymphocytes, Helper-Inducer/*drug effects
MH  - Th1 Cells/drug effects
MH  - Th2 Cells/drug effects
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2001/02/24 12:00
MHDA- 2001/04/06 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/04/06 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1111/j.8755-8920.2000.440604.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2000 Dec;44(6):342-6. doi: 
      10.1111/j.8755-8920.2000.440604.x.