PMID- 11200937
OWN - NLM
STAT- MEDLINE
DCOM- 20010301
LR  - 20221207
IS  - 0918-8959 (Print)
IS  - 0918-8959 (Linking)
VI  - 47
IP  - 5
DP  - 2000 Oct
TI  - Frequency of facial angiofibromas in Japanese patients with multiple endocrine 
      neoplasia type 1.
PG  - 569-73
AB  - The high frequency of cutaneous manifestations in patients with multiple 
      endocrine neoplasia type 1 (MEN 1) has recently been reported. Since prevalence 
      of some cutaneous diseases varies among different ethnic groups, we examined the 
      frequency of facial angiofibromas in Japanese patients with familial MEN 1. Among 
      27 patients with germline MEN1 gene mutation and one asymptomatic gene carrier, 
      angiofibromas were identified in 43% (12/28) of the subjects. This frequency was 
      significantly lower than that of Caucasian patients, but nonetheless almost 
      equaled those of pituitary tumors and pancreas endocrine tumors. Angiofibromas 
      should be considered as one of major manifestations in MEN 1 regardless of 
      patients' ethnic origin, and clinicians should pay careful attention to the 
      cutaneous lesions in patients with endocrine tumors.
FAU - Sakurai, A
AU  - Sakurai A
AD  - Department of Aging Medicine and Geriatrics, Shinshu University, Matsumoto, 
      Japan.
FAU - Matsumoto, K
AU  - Matsumoto K
FAU - Ikeo, Y
AU  - Ikeo Y
FAU - Nishio, S I
AU  - Nishio SI
FAU - Kakizawa, T
AU  - Kakizawa T
FAU - Arakura, F
AU  - Arakura F
FAU - Ishihara, Y
AU  - Ishihara Y
FAU - Saida, T
AU  - Saida T
FAU - Hashizume, K
AU  - Hashizume K
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiofibroma/diagnosis/ethnology/*genetics
MH  - Asian People/genetics
MH  - *Face
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/*genetics
MH  - Neoplasm Proteins/genetics
MH  - *Proto-Oncogene Proteins
MH  - Skin Neoplasms/ethnology/*genetics
EDAT- 2001/02/24 12:00
MHDA- 2001/03/07 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/07 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1507/endocrj.47.569 [doi]
PST - ppublish
SO  - Endocr J. 2000 Oct;47(5):569-73. doi: 10.1507/endocrj.47.569.