PMID- 11201034
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20190906
IS  - 0364-2348 (Print)
IS  - 0364-2348 (Linking)
VI  - 29
IP  - 11
DP  - 2000 Nov
TI  - Malignant round cell tumours of bone: atypical clinical and imaging features.
PG  - 646-51
AB  - OBJECTIVE: To describe the clinical, radiological and MRI features of six 
      atypical cases of histologically proven appendicular Ewing sarcoma/primitive 
      neuroectodermal tumour (PNET). DESIGN: Retrospective review of case notes and 
      available imaging was carried out. PATIENTS: Six patients (4 male, 2 female; mean 
      age 27 years, range 19-44 years), presenting over a 77-month period, were 
      identified from the Bone Tumour Register. All had unusual clinical and imaging 
      features for Ewing sarcoma/PNET. RESULTS AND CONCLUSIONS: Four tumours were 
      centred on the distal femoral metaphysis, one in the proximal tibial metaphysis 
      and one in the distal tibial metaphysis. Plain radiographs were available in four 
      cases and showed minor cortical changes. MRI demonstrated a relatively small, 
      eccentrically located intraosseous component with a large, eccentric extraosseous 
      component. Extension into the epiphysis was seen in three cases and into the 
      adjacent joint in two cases. Intraosseous "skip" metastases were present in three 
      cases. The clinical and imaging features were atypical for conventional 
      intraosseous Ewing sarcoma/PNET and the exact site of origin (intraosseous, 
      periosteal or soft-tissue) was unclear.
FAU - Saifuddin, A
AU  - Saifuddin A
AD  - Department of Radiology, The Royal National Orthopaedic Hospital Trust, Stanmore, 
      Middlesex, UK.
FAU - Whelan, J
AU  - Whelan J
FAU - Pringle, J A
AU  - Pringle JA
FAU - Cannon, S R
AU  - Cannon SR
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Skeletal Radiol
JT  - Skeletal radiology
JID - 7701953
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor/analysis
MH  - Bone Neoplasms/*diagnosis/pathology
MH  - Epiphyses/pathology
MH  - Female
MH  - Femoral Neoplasms/*diagnosis/pathology
MH  - Follow-Up Studies
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Neuroectodermal Tumors, Primitive/*diagnosis/pathology
MH  - Sarcoma, Ewing/*diagnosis/pathology
MH  - Tibia/*pathology
EDAT- 2001/02/24 12:00
MHDA- 2001/05/01 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1007/s002560000277 [doi]
PST - ppublish
SO  - Skeletal Radiol. 2000 Nov;29(11):646-51. doi: 10.1007/s002560000277.