PMID- 11201671
OWN - NLM
STAT- MEDLINE
DCOM- 20010322
LR  - 20190906
IS  - 0340-5761 (Print)
IS  - 0340-5761 (Linking)
VI  - 74
IP  - 10
DP  - 2000 Dec
TI  - Suppression of decidual cell response induced by tributyltin chloride in 
      pseudopregnant rats: a cause of early embryonic loss.
PG  - 632-7
AB  - In our previous studies, tributyltin chloride (TBTCl) at doses of 16.3 mg/kg and 
      above caused implantation failure (preimplantation embryonic loss) and 
      postimplantation embryonic loss in rats following administration on gestational 
      day (GD) 0 through GD 3 and GD 4 through GD 7, respectively. This study was 
      designed to assess the effects of TBTCl on uterine function as a cause of early 
      embryonic loss in pseudopregnant rats. TBTCl was given orally to pseudopregnant 
      rats at doses of 4.1, 8.1, 16.3 and 32.5 mg/kg on pseudopregnant day (PPD) 0 to 
      PPD 3 or 8.1, 16.3, 32.5 and 65.1 mg/kg on PPD 4 to PPD 7. The decidual cell 
      response was induced by bilateral scratch trauma on PPD 4. The uterine weight on 
      PPD 9 served as an index of uterine decidualization. Uterine weight and serum 
      progesterone levels on PPD 9 were significantly decreased after administration of 
      TBTCl at doses of 16.3 mg/kg and above on PPD 0 to PPD 3 or PPD 4 to PPD 7. 
      Administration of TBTCl at doses of 8.1 mg/kg and above on PPD 0 to 3 also 
      significantly decreased serum progesterone levels on PPD 4. TBTCl had no effect 
      on ovarian weight and number of corpora lutea. It can be concluded that TBTCl 
      suppresses the uterine decidual cell response and decreases progesterone levels, 
      and these effects are responsible for early embryonic loss due to TBTCl exposure.
FAU - Harazono, A
AU  - Harazono A
AD  - National Institute of Health Sciences, Osaka Branch, Japan. harazono@nihs.go.jp
FAU - Ema, M
AU  - Ema M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Arch Toxicol
JT  - Archives of toxicology
JID - 0417615
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Trialkyltin Compounds)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 4XDX163P3D (tributyltin)
SB  - IM
MH  - Animals
MH  - Corpus Luteum/drug effects/pathology
MH  - Eating/drug effects
MH  - Embryo Implantation/*drug effects/physiology
MH  - Embryo Loss/chemically induced/*etiology
MH  - Estradiol/blood
MH  - Female
MH  - Fungicides, Industrial/*toxicity
MH  - Organ Size/drug effects
MH  - Ovary/drug effects/pathology
MH  - Progesterone/blood
MH  - Pseudopregnancy/blood
MH  - Rats
MH  - Rats, Wistar
MH  - Trialkyltin Compounds/*toxicity
MH  - Uterus/drug effects/pathology
EDAT- 2001/02/24 12:00
MHDA- 2001/03/27 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/27 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1007/s002040000163 [doi]
PST - ppublish
SO  - Arch Toxicol. 2000 Dec;74(10):632-7. doi: 10.1007/s002040000163.