PMID- 11203736
OWN - NLM
STAT- MEDLINE
DCOM- 20010419
LR  - 20181130
IS  - 1064-6655 (Print)
IS  - 1064-6655 (Linking)
VI  - 14
IP  - 1
DP  - 2000 Winter
TI  - Plasma and serum serotonin levels and their relationship to orofacial pain and 
      anxiety in fibromyalgia.
PG  - 37-46
AB  - AIMS: Serum serotonin levels (S-5-HT) have been reported to be reduced in 
      patients with fibromyalgia and to show a negative correlation with pain. We 
      hypothesized that one mechanism behind this could be that platelets are activated 
      to release 5-HT into the plasma compartment (P-5-HT), which then binds to 
      nociceptors. The aims of this study were therefore to investigate the relation 
      between P-5-HT and S-5-HT and their relationship versus orofacial pain and 
      anxiety in fibromyalgia. METHODS: Twelve patients with fibromyalgia, 12 patients 
      with rheumatoid arthritis, and 12 healthy individuals participated in the study. 
      Pain measures used were pain intensity assessed with a visual analog scale, pain 
      drawings, and influence of pain on daily living activities (ADL). The Spielberger 
      State and Trait Anxiety Inventory (STAI) scale was used for self-rating of 
      anxiety levels. The participants were examined clinically, and the pressure pain 
      threshold (PPT) over the masseter muscle was assessed. Finally, venous blood was 
      collected for analysis of P-5-HT and S-5-HT. RESULTS: The ratio between P-5-HT 
      and S-5-HT was calculated to determine the relative plasma fraction of serotonin 
      (RPS). Patients with fibromyalgia showed significantly lower S-5-HT than did 
      patients with rheumatoid arthritis. They also showed significantly higher STAI 
      scores and tender point index of orofacial muscles and significantly lower PPT 
      than the healthy individuals. High RPS was associated with high ADL and STAI 
      scores. CONCLUSION: This study indicates that a high level of plasma serotonin in 
      relation to serum level is associated with pain discomfort and increased anxiety 
      in fibromyalgia.
FAU - Ernberg, M
AU  - Ernberg M
AD  - Department of Clinical Oral Physiology, Karolinska Institutet, Huddinge, Sweden. 
      malin.ernberg@ofa.ki.se
FAU - Voog, U
AU  - Voog U
FAU - Alstergren, P
AU  - Alstergren P
FAU - Lundeberg, T
AU  - Lundeberg T
FAU - Kopp, S
AU  - Kopp S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Orofac Pain
JT  - Journal of orofacial pain
JID - 9418507
RN  - 333DO1RDJY (Serotonin)
MH  - Activities of Daily Living
MH  - Anxiety/*blood/classification/physiopathology
MH  - Arthritis, Rheumatoid/blood/physiopathology/psychology
MH  - Blood Platelets/metabolism
MH  - Case-Control Studies
MH  - Facial Muscles/physiopathology
MH  - Facial Pain/*blood/physiopathology/psychology
MH  - Female
MH  - Fibromyalgia/*blood/physiopathology/psychology
MH  - Humans
MH  - Masseter Muscle/physiopathology
MH  - Middle Aged
MH  - Nociceptors/metabolism
MH  - Pain Measurement
MH  - Pain Threshold/physiology
MH  - Plasma
MH  - Serotonin/*blood
MH  - Statistics, Nonparametric
EDAT- 2001/02/24 12:00
MHDA- 2001/04/21 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/04/21 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
PST - ppublish
SO  - J Orofac Pain. 2000 Winter;14(1):37-46.