PMID- 11204811
OWN - NLM
STAT- MEDLINE
DCOM- 20010329
LR  - 20190906
IS  - 0954-691X (Print)
IS  - 0954-691X (Linking)
VI  - 13
IP  - 1
DP  - 2001 Jan
TI  - Diagnostic value of plasma chromogranin A in neuroendocrine tumours.
PG  - 55-8
AB  - AIM: The aim of this study was to assess the value of plasma chromogranin A 
      (CgA), a protein produced by neuroendocrine cells, in the diagnosis of 
      neuroendocrine tumours. METHODS: Eighty subjects with neuroendocrine tumours were 
      studied. Thirty-four had carcinoids, 21 nonfunctioning endocrine pancreatic 
      tumours, 17 multiple endocrine neoplasia type 1 (MEN 1) (six of these also had 
      gastrinomas), and eight had functioning pancreatic tumours (four gastrinomas, two 
      glucagonomas, two somatostatinomas). Twenty-eight healthy subjects were studied 
      as controls. A fasting plasma sample was obtained from each subject, and CgA 
      plasma levels were measured by the ELISA method using a kit (Dako A/S, Denmark). 
      RESULTS: In control subjects, plasma CgA values were below 5 U/l. Among the 
      patients, 20 of the 34 with carcinoid tumours, 12 of the 21 with nonfunctioning 
      pancreatic tumours, nine of the 17 with MEN 1 (including the six with 
      gastrinomas), and the four gastrinomas of the eight functioning pancreatic 
      tumours, i.e. overall, 45 of the 80 patients (56.3%) had abnormally high CgA 
      values (22-961 U/l). Most of the patients with elevated CgA values, except nine 
      of the 10 with gastrinomas, had multiple liver metastasis. CONCLUSIONS: The 
      results show that the diagnostic value of plasma CgA in neuroendocrine tumours is 
      relatively low; it may be of some interest only in patients with advanced disease 
      and liver metastasis. Gastrinoma seems to be an exception, because in this tumour 
      high CgA values are generally found even in the absence of liver metastasis.
FAU - Tomassetti, P
AU  - Tomassetti P
AD  - Department of Internal Medicine and Gastroenterology, University of Bologna, 
      Italy. tomasset@med.unibo.it
FAU - Migliori, M
AU  - Migliori M
FAU - Simoni, P
AU  - Simoni P
FAU - Casadei, R
AU  - Casadei R
FAU - De Iasio, R
AU  - De Iasio R
FAU - Corinaldesi, R
AU  - Corinaldesi R
FAU - Gullo, L
AU  - Gullo L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
RN  - 0 (CHGA protein, human)
RN  - 0 (Chromogranin A)
RN  - 0 (Chromogranins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoid Tumor/blood
MH  - Chromogranin A
MH  - Chromogranins/*blood
MH  - Female
MH  - Gastrinoma/blood
MH  - Humans
MH  - Liver Neoplasms/secondary
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/blood
MH  - Neuroendocrine Tumors/*diagnosis
MH  - Pancreatic Neoplasms/*diagnosis
EDAT- 2001/02/24 12:00
MHDA- 2001/04/03 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/04/03 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1097/00042737-200101000-00010 [doi]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 2001 Jan;13(1):55-8. doi: 
      10.1097/00042737-200101000-00010.