PMID- 11208339
OWN - NLM
STAT- MEDLINE
DCOM- 20011011
LR  - 20061115
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 6
IP  - 2
DP  - 2000 Mar-Apr
TI  - Peptic ulcer disease before and after introduction of new drugs--a comparison 
      from surgeon's point of view.
PG  - 365-8
AB  - During the last twenty years we have witnessed a revolutionary change in 
      treatment and diagnosis of peptic ulcer disease (PUD). It was introduction of 
      flexible fiberoptic instruments and new drugs: H-2 blockers, proton pump 
      inhibitors (PPI) and treatment against Helicobacter pylori which affected most 
      significantly the course of this illness. Although indications for surgical 
      intervention have not been changed, practice of surgery in this regard has 
      changed a lot. In this report two periods of time were analyzed and compared: 
      years 1977-81 and 1992-96. Operation reports from the above defined periods were 
      reviewed and all surgeries performed for PUD and its complications have been 
      noted along with data regarding patients and indications for surgery as reported 
      by operating surgeons. There were 360 surgeries for PUD performed in the 
      1977-1981 period, and 246 in the years 1992-1996. Patients were divided into 
      groups depending on indications for surgery. A significant reduction in the 
      general number of operations performed was noted. The percentage of women 
      operated upon increased. The mean age of patients in all indication groups was 
      higher in the latter period. Patients operated for bleeding tended to be older 
      than those in perforation and intractable disease groups. This was true in both 
      periods of time. The number and percentage of patients operated for perforation 
      increased. The natural course of PUD is changing; intractable disease as an 
      indication for surgery is disappearing, the number of pyloric obstruction 
      patients is diminishing, the incidence of bleeding and perforation remains 
      constant. The mean age of patients and percentage of women is increasing.
FAU - Janik, J
AU  - Janik J
AD  - Department of Surgery, M. Kopernik Hospital, Gdansk, Poland. jurekj@polbox.com
FAU - Chwirot, P
AU  - Chwirot P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
SB  - IM
MH  - Adult
MH  - Digestive System Surgical Procedures/trends
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptic Ulcer/complications/*drug therapy/*surgery
MH  - Poland
MH  - Time Factors
EDAT- 2001/02/24 11:00
MHDA- 2001/10/12 10:01
CRDT- 2001/02/24 11:00
PHST- 2001/02/24 11:00 [pubmed]
PHST- 2001/10/12 10:01 [medline]
PHST- 2001/02/24 11:00 [entrez]
AID - 1215 [pii]
PST - ppublish
SO  - Med Sci Monit. 2000 Mar-Apr;6(2):365-8.