PMID- 11208623
OWN - NLM
STAT- MEDLINE
DCOM- 20010531
LR  - 20220321
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 163
IP  - 1
DP  - 2001 Jan
TI  - Airway responsiveness in early infancy predicts asthma, lung function, and 
      respiratory symptoms by school age.
PG  - 37-42
AB  - Asthma is the most common chronic childhood disease in developed nations. Little 
      is known about the relationship between airway responsiveness in infancy and the 
      development of asthma later in life. The relationship of airway responsiveness at 
      1 mo with asthma, atopy, lower respiratory symptoms, and lung function at 6 yr of 
      age was investigated prospectively in 95 white children from a randomly 
      ascertained birth cohort. Baseline spirometry, airway responsiveness to 
      histamine, and skin reactivity to common allergens were assessed at the age of 1 
      mo and 6 yr. Total serum immunoglobulin E (IgE) was measured from cord blood and 
      at 6 yr. Blood eosinophil counts were measured at 6 yr only. Family, symptom, and 
      exposure histories at both time points were derived from questionnaire data. 
      Independently of the other factors assessed, increased airway responsiveness at 1 
      mo was significantly associated with the following parameters measured at six yr: 
      decreased FEV(1) (p < 0.001); decreased FVC (p < 0.001); physician-diagnosed 
      asthma (p < 0.001); and lower respiratory tract symptoms (p < 0.05). None of the 
      other physiologic factors measured in infancy showed such consistent associations 
      with important clinical and physiologic outcomes at age 6. These data suggest 
      that airway responsiveness in early life defines a functional state that is 
      associated with abnormal airway function, lower respiratory symptoms, and the 
      emergence of asthma by 6 yr of age.
FAU - Palmer, L J
AU  - Palmer LJ
AD  - Department of Paediatrics, University of Western Australia, Perth, Australia. 
      reljp@channing.harvard.edu
FAU - Rye, P J
AU  - Rye PJ
FAU - Gibson, N A
AU  - Gibson NA
FAU - Burton, P R
AU  - Burton PR
FAU - Landau, L I
AU  - Landau LI
FAU - Lesouef, P N
AU  - Lesouef PN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
SB  - IM
MH  - Age Factors
MH  - Asthma/*etiology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Forecasting
MH  - Humans
MH  - Infant
MH  - Lung/immunology/*physiology
MH  - Lung Diseases/*etiology
MH  - Male
MH  - Prospective Studies
EDAT- 2001/02/24 11:00
MHDA- 2001/06/02 10:01
CRDT- 2001/02/24 11:00
PHST- 2001/02/24 11:00 [pubmed]
PHST- 2001/06/02 10:01 [medline]
PHST- 2001/02/24 11:00 [entrez]
AID - 10.1164/ajrccm.163.1.2005013 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2001 Jan;163(1):37-42. doi: 
      10.1164/ajrccm.163.1.2005013.