PMID- 11208925
OWN - NLM
STAT- MEDLINE
DCOM- 20020815
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 76
IP  - 2
DP  - 2001 Jan
TI  - Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary 
      restriction in mice.
PG  - 619-26
AB  - Dietary restriction (DR; reduced calorie intake) increases the lifespan of 
      rodents and increases their resistance to cancer, diabetes and other age-related 
      diseases. DR also exerts beneficial effects on the brain including enhanced 
      learning and memory and increased resistance of neurons to excitotoxic, oxidative 
      and metabolic insults. The mechanisms underlying the effects of DR on neuronal 
      plasticity and survival are unknown. In the present study we show that levels of 
      brain-derived neurotrophic factor (BDNF) are significantly increased in the 
      hippocampus, cerebral cortex and striatum of mice maintained on an alternate day 
      feeding DR regimen compared to animals fed ad libitum. Damage to hippocampal 
      neurons induced by the excitotoxin kainic acid was significantly reduced in mice 
      maintained on DR, and this neuroprotective effect was attenuated by 
      intraventricular administration of a BDNF-blocking antibody. Our findings show 
      that simply reducing food intake results in increased levels of BDNF in brain 
      cells, and suggest that the resulting activation of BDNF signaling pathways plays 
      a key role in the neuroprotective effect of DR. These results bolster 
      accumulating evidence that DR may be an effective approach for increasing the 
      resistance of the brain to damage and enhancing brain neuronal plasticity.
FAU - Duan, W
AU  - Duan W
AD  - Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland 
      21224, USA.
FAU - Guo, Z
AU  - Guo Z
FAU - Mattson, M P
AU  - Mattson MP
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotoxins)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Antibodies/administration & dosage
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/antagonists & inhibitors/*metabolism
MH  - Cell Count
MH  - Cell Survival/drug effects
MH  - Cerebral Cortex/cytology/metabolism
MH  - Corpus Striatum/cytology/metabolism
MH  - Cytoprotection
MH  - *Diet
MH  - Energy Intake
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/cytology/drug effects/*metabolism
MH  - Injections, Intraventricular
MH  - Kainic Acid/administration & dosage
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuronal Plasticity/physiology
MH  - Neurons/cytology/drug effects/*metabolism
MH  - Neurotoxins/administration & dosage
MH  - Signal Transduction/physiology
EDAT- 2001/02/24 11:00
MHDA- 2002/08/16 10:01
CRDT- 2001/02/24 11:00
PHST- 2001/02/24 11:00 [pubmed]
PHST- 2002/08/16 10:01 [medline]
PHST- 2001/02/24 11:00 [entrez]
AID - 10.1046/j.1471-4159.2001.00071.x [doi]
PST - ppublish
SO  - J Neurochem. 2001 Jan;76(2):619-26. doi: 10.1046/j.1471-4159.2001.00071.x.