PMID- 11209065
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20230331
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 98
IP  - 2
DP  - 2001 Jan 16
TI  - Emotion-induced changes in human medial prefrontal cortex: I. During cognitive 
      task performance.
PG  - 683-7
AB  - Regional cerebral blood flow (BF) was examined in regions of the medial 
      prefrontal cortex (MPFC) with positron-emission tomography while subjects 
      performed two cognitive tasks, reading nouns aloud and generating appropriate 
      verbs for the same nouns. The control task was passive viewing of the same words. 
      BF was reduced in regions of the MPFC during word reading and naive verb 
      generation, relative to a control state in which the subjects passively viewed 
      nouns. Practicing verb generation produced improved performance, as measured by 
      response time, which was strongly correlated with further reductions in MPFC and 
      hypothalamic BF. After practice, when verb generation was performed on a novel 
      list of words, reaction times slowed and the pattern of MPFC BF reverted to that 
      seen in the word reading and naive conditions. A separate behavioral study of the 
      verb-generation task indicated that anxiety, high during naive use-generation as 
      measured by heart rate and self-report, decreased with practice on the task but 
      returned with the introduction of a novel list of words. Taken together, these 
      results suggest that the MPFC is part of a network, including the hypothalamus 
      and brainstem, whose activity reflects a dynamic interplay between cognitive task 
      performance and emotion.
FAU - Simpson, J R Jr
AU  - Simpson JR Jr
AD  - Mallinckrodt Institute of Radiology, and Departments of Anatomy and Neurobiology, 
      Psychiatry, and Neurology, Washington University School of Medicine, St Louis, 
      MO, 63110, USA.
FAU - Snyder, A Z
AU  - Snyder AZ
FAU - Gusnard, D A
AU  - Gusnard DA
FAU - Raichle, M E
AU  - Raichle ME
LA  - eng
GR  - P50 NS006833/NS/NINDS NIH HHS/United States
GR  - NS06833/NS/NINDS NIH HHS/United States
GR  - NS10196/NS/NINDS NIH HHS/United States
GR  - F31 NS010196/NS/NINDS NIH HHS/United States
GR  - DA07261/DA/NIDA NIH HHS/United States
GR  - T32 DA007261/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
MH  - Adult
MH  - Anxiety/*physiopathology
MH  - Brain Stem/diagnostic imaging/physiology
MH  - Cognition/*physiology
MH  - Emotions/*physiology
MH  - Female
MH  - Habituation, Psychophysiologic/physiology
MH  - Heart Rate
MH  - Humans
MH  - Hypothalamus/diagnostic imaging/physiology
MH  - Language Tests
MH  - Male
MH  - Neuropsychological Tests
MH  - Prefrontal Cortex/diagnostic imaging/*physiology
MH  - Psychomotor Performance/physiology
MH  - Reaction Time
MH  - Reading
MH  - Tomography, Emission-Computed
PMC - PMC14648
EDAT- 2001/02/24 11:00
MHDA- 2001/05/01 10:01
PMCR- 2001/07/16
CRDT- 2001/02/24 11:00
PHST- 2001/02/24 11:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/02/24 11:00 [entrez]
PHST- 2001/07/16 00:00 [pmc-release]
AID - 98/2/683 [pii]
AID - 5126 [pii]
AID - 10.1073/pnas.98.2.683 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):683-7. doi: 10.1073/pnas.98.2.683.