PMID- 11209066
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20230331
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 98
IP  - 2
DP  - 2001 Jan 16
TI  - Emotion-induced changes in human medial prefrontal cortex: II. During 
      anticipatory anxiety.
PG  - 688-93
AB  - Regional cerebral blood flow (BF) was examined in the human medial prefrontal 
      cortex (MPFC) with positron emission tomography during anticipatory anxiety. 
      Transient anxiety was induced in normal subjects by having them anticipate a 
      painful shock to the fingers of one hand. BF was decreased during anticipatory 
      anxiety, relative to an eyes-closed resting condition, in two regions of the MPFC 
      (Brodmann Areas 10/32 and 24/25). BF decreases in these areas were inversely 
      correlated with anxiety self rating, such that the least anxious subjects 
      exhibited the largest BF reductions, whereas the most anxious subjects showed no 
      significant BF reduction or a slight increase. BF changes in MPFC and in the 
      midbrain were correlated with each other and with anxiety self rating. These 
      results are consistent with the hypothesis that BF reductions in MPFC, previously 
      observed in cognitive tasks, reflect a dynamic balance between focused attention 
      and subject anxiety and may occur from a functionally active baseline or default 
      state. The characterization of such relationships within the human brain enables 
      new insights into the integration of cognition and emotion.
FAU - Simpson, J R Jr
AU  - Simpson JR Jr
AD  - Mallinckrodt Institute of Radiology, and Departments of Anatomy and Neurobiology, 
      Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO 
      63110, USA.
FAU - Drevets, W C
AU  - Drevets WC
FAU - Snyder, A Z
AU  - Snyder AZ
FAU - Gusnard, D A
AU  - Gusnard DA
FAU - Raichle, M E
AU  - Raichle ME
LA  - eng
GR  - P50 NS006833/NS/NINDS NIH HHS/United States
GR  - NS06833/NS/NINDS NIH HHS/United States
GR  - R01 DC000093/DC/NIDCD NIH HHS/United States
GR  - NS10196/NS/NINDS NIH HHS/United States
GR  - F31 NS010196/NS/NINDS NIH HHS/United States
GR  - DA07261/DA/NIDA NIH HHS/United States
GR  - DC000093/DC/NIDCD NIH HHS/United States
GR  - T32 DA007261/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
MH  - Adult
MH  - Anxiety/*physiopathology
MH  - Electroshock/*psychology
MH  - Emotions/*physiology
MH  - Female
MH  - Habituation, Psychophysiologic/physiology
MH  - Heart Rate
MH  - Humans
MH  - Hypothalamus/diagnostic imaging/physiology
MH  - Male
MH  - Mesencephalon/diagnostic imaging/physiology
MH  - Pain/physiopathology/*psychology
MH  - Prefrontal Cortex/diagnostic imaging/*physiology
MH  - Reaction Time
MH  - Tomography, Emission-Computed
PMC - PMC14649
EDAT- 2001/02/24 11:00
MHDA- 2001/05/01 10:01
PMCR- 2001/07/16
CRDT- 2001/02/24 11:00
PHST- 2001/02/24 11:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/02/24 11:00 [entrez]
PHST- 2001/07/16 00:00 [pmc-release]
AID - 98/2/688 [pii]
AID - 5127 [pii]
AID - 10.1073/pnas.98.2.688 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):688-93. doi: 10.1073/pnas.98.2.688.