PMID- 11209133
OWN - NLM
STAT- MEDLINE
DCOM- 20010405
LR  - 20220310
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 44
IP  - 3
DP  - 2001 Mar
TI  - Immunohistochemical detection of the c-met proto-oncogene product in the 
      congenital melanocytic nevus of an infant with neurocutaneous melanosis.
PG  - 538-40
AB  - Transgenic mice overexpressing hepatocyte growth factor/scatter factor (HGF/SF) 
      demonstrate extensive pigmented nevi in both skin and leptomeninges of the 
      central nervous system resembling human neurocutaneous melanosis. We 
      immunohistochemically detected HGF/SF receptor, Met, in a congenital nevus of an 
      infant with neurocutaneous melanosis, indicating that deregulation of HGF/SF-Met 
      signaling in the critical period of development may lead to this fatal syndrome.
FAU - Takayama, H
AU  - Takayama H
AD  - First Department of Internal Medicine, Gunma University School of Medicine, 
      Maebashi, Japan. hitakaya@showa.gunma-u.ac.jp
FAU - Nagashima, Y
AU  - Nagashima Y
FAU - Hara, M
AU  - Hara M
FAU - Takagi, H
AU  - Takagi H
FAU - Mori, M
AU  - Mori M
FAU - Merlino, G
AU  - Merlino G
FAU - Nakazato, Y
AU  - Nakazato Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Child, Preschool
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Melanosis/*genetics/immunology
MH  - Mice
MH  - Neurocutaneous Syndromes/*genetics/immunology
MH  - Nevus, Pigmented/*congenital/immunology/pathology
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins c-met/*analysis/immunology
MH  - Signal Transduction
EDAT- 2001/02/24 11:00
MHDA- 2001/04/06 10:01
CRDT- 2001/02/24 11:00
PHST- 2001/02/24 11:00 [pubmed]
PHST- 2001/04/06 10:01 [medline]
PHST- 2001/02/24 11:00 [entrez]
AID - S0190-9622(01)75419-9 [pii]
AID - 10.1067/mjd.2001.112403 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2001 Mar;44(3):538-40. doi: 10.1067/mjd.2001.112403.