PMID- 11209967
OWN - NLM
STAT- MEDLINE
DCOM- 20010322
LR  - 20190921
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 32
IP  - 9
DP  - 2000 Dec
TI  - Immunopathogenesis of HTLV-I-associated myelopathy/tropical spastic paraparesis.
PG  - 600-7
AB  - The main pathological feature of human T-lymphotropic virus type I 
      (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic 
      inflammation of the spinal cord characterized by perivascular cuffing of 
      mononuclear cells accompanied by parenchymal lymphocytic infiltration. Although 
      the exact mechanism of the pathogenesis of HAM/TSP is still obscure, 
      immunological abnormalities arising from a high HTLV-I proviral load in 
      peripheral blood lymphocytes (PBL) play an important role in the pathological 
      process of spinal cord lesions in HAM/TSP patients. The relationship between HLA 
      haplotype and the risk of the occurrence of HAM/TSP will be elucidated by results 
      from studies of HLA allele typing. In addition, recent data indicate that HTLV-I 
      and its expression are localized in infiltrated lymphocytes within the spinal 
      cord lesions of HAM/TSP patients rather than in resident central nervous system 
      (CNS) parenchymal cells. Although a bystander damage of the surrounding CNS 
      tissues, in which CD8+ HTLV-I-specific cytotoxic T lymphocyte (CTL) attack 
      HTLV-I-infected lymphocytes, might be involved in the pathological events of the 
      spinal cords of HAM/ TSP patients as one of the actual pathogenetic mechanisms, 
      heightened transmigrating activity of HTLV-I-infected CD4+ T lymphocytes to the 
      CNS tissues may have a key role in the development of HAM/TSP. Therefore, 
      although the exact mechanism underlying the high HTLV-I proviral load in PBL in 
      HAM/TSP patients is still unknown, we must consider therapeutic approaches in 
      HAM/TSP that eliminate HTLV-I-infected CD4+ T lymphocytes.
FAU - Nakamura, T
AU  - Nakamura T
AD  - First Department of Internal Medicine, Nagasaki University School of Medicine, 
      Japan. tatsu@net.nagasaki-u.ac.jp
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
SB  - IM
MH  - Adult
MH  - Antibody Formation
MH  - Human T-lymphotropic virus 1/*pathogenicity
MH  - Humans
MH  - *Paraparesis, Tropical Spastic/etiology/immunology/physiopathology
RF  - 69
EDAT- 2001/02/24 12:00
MHDA- 2001/03/27 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/27 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.3109/07853890009002030 [doi]
PST - ppublish
SO  - Ann Med. 2000 Dec;32(9):600-7. doi: 10.3109/07853890009002030.