PMID- 11210867
OWN - NLM
STAT- MEDLINE
DCOM- 20010222
LR  - 20131121
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 111
IP  - 2
DP  - 2001 Feb
TI  - Changes in serum interferon-gamma, interleukin-4, and interleukin-12 cytokine 
      levels in anti-histamine type 2-treated allergic rhinitis patients.
PG  - 236-9
AB  - OBJECTIVES/HYPOTHESIS: Markedly elevated immunoglobulin E (IgE) synthesis 
      characterizes allergic diseases. Interferon-gamma (IFN-gamma) and interleukin-4 
      (IL-4) regulate IgE synthesis. It has been shown that immunotherapy and histamine 
      type 2 (H2) receptor antagonists induce a clinical improvement, decrease IgE 
      antibodies, and increase T-cell subsets, which express a suppressor function. In 
      addition, immunotherapy brings about a reduction in the amount of IL-4 in T-cell 
      clones of allergic individuals. The purpose of this study was to investigate the 
      profile of cytokines IFNgamma and IL-4 that occurs in vivo in anti-H2-treated 
      patients with allergic rhinitis (AR). METHODS: Enrolled were 65 AR patients with 
      sensitivity to a single allergen, the Parietaria, 36 of whom were randomly 
      assigned to treatment with ranitidine at a dosage of 1 mg/kg per day 
      intravenously for 20 days, and 29 to placebo treatment. RESULTS: A comparison of 
      the serum cytokine values recorded before and after anti-H2 treatment showed a 
      significant increase in INF-gamma serum level (P = .003) and a decrease in IL-4 
      (P = .016). Negligible variations were found in the placebo-treated group. 
      CONCLUSION: H2 antagonists probably induce their effects by enhancing the amount 
      of IFN-gamma and by reducing IL-4 cytokines, which, respectively, induce a 
      decrease and an increase in the IgE synthesis.
FAU - Testa, B
AU  - Testa B
AD  - Institute of Otolaryngology, School of Medicine, Second University of Naples, 
      Italy.
FAU - Mesolella, C
AU  - Mesolella C
FAU - Mosti, M R
AU  - Mosti MR
FAU - Mesolella, M
AU  - Mesolella M
FAU - Testa, D
AU  - Testa D
FAU - Motta, G
AU  - Motta G
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Cytokines)
RN  - 0 (Histamine H2 Antagonists)
RN  - 187348-17-0 (Interleukin-12)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 884KT10YB7 (Ranitidine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cytokines/*blood
MH  - Female
MH  - Histamine H2 Antagonists/adverse effects/*therapeutic use
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/*blood
MH  - Interleukin-12/*blood
MH  - Interleukin-4/*blood
MH  - Male
MH  - Middle Aged
MH  - Ranitidine/adverse effects/*therapeutic use
MH  - Rhinitis, Allergic, Seasonal/*drug therapy/immunology
MH  - Treatment Outcome
EDAT- 2001/02/24 12:00
MHDA- 2001/03/03 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1097/00005537-200102000-00009 [doi]
PST - ppublish
SO  - Laryngoscope. 2001 Feb;111(2):236-9. doi: 10.1097/00005537-200102000-00009.