PMID- 11210944
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20200516
IS  - 0920-8569 (Print)
IS  - 0920-8569 (Linking)
VI  - 22
IP  - 1
DP  - 2001 Jan
TI  - The hamster polyomavirus--a brief review of recent knowledge.
PG  - 93-101
AB  - The hamster polyomavirus (HaPV) was first described in 1967 as a virus associated 
      with skin epithelioma of the Syrian hamster. The tumors appear spontaneously in a 
      hamster colony bred in Berlin-Buch (HaB). Virus particles isolated from skin 
      epitheliomas cause lymphoma and leukemia when injected into newborn hamsters from 
      a distinct colony bred in Potsdam, Germany (HaP). The viral genome has been 
      totally sequenced and the overall genetic organization establishes HaPV as a 
      member of the polyomaviruses. HaPV is a second example of an middle T (MT) 
      antigen encoding polyomavirus and nucleotide sequence homologies designates the 
      mouse polyomavirus (Py) as the closest relative. Lymphomas induced by HaPV in HaP 
      hamsters do not contain virus particles but instead accumulate different amounts 
      of nonrandomly deleted free and/or integrated viral genomes. Transgenic mice 
      produced by microinjection of HaPV DNA into the pronucleus of fertilized eggs of 
      Gat: NMRI mice developed both, epitheliomas and lymphomas. Both tumor types 
      contain extrachromosomal DNA. HaPV DNA was found to replicate in hamster lymphoid 
      and fibroblast cell lines. Fully reproductive cycles could be detected only in 
      GD36 lymphoblastic leukemia cells. HaPV carries the full transforming properties 
      of a polyomavirus in vitro. Immortalization of primary rat cells is essentially 
      carried out by the HaPV large T (LT) antigen and coexpression of HaPV MT and HaPV 
      small T (ST) antigen is required for full transformation of rat fibroblasts. The 
      preferential binding of HaPV MT to c-Fyn, a Src family kinase, has been proposed 
      as a mechanism leading to lymphoid malignancies. Heterologous expression of 
      HaPV-VP1 allowed the formation of virus like particles (VLPs) resembling HaPV 
      particles. The high flexibility of HaPV-VP1 for insertion of foreign peptides 
      offers a broad range of potential applications, especially in vaccine 
      development.
FAU - Scherneck, S
AU  - Scherneck S
AD  - Max Delbruck Center for Molecular Medicine, Berlin, Germany. 
      sschern@mdc-berlin.de
FAU - Ulrich, R
AU  - Ulrich R
FAU - Feunteun, J
AU  - Feunteun J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Virus Genes
JT  - Virus genes
JID - 8803967
SB  - IM
MH  - Animals
MH  - Cricetinae
MH  - Mesocricetus
MH  - Mice
MH  - Papilloma/*virology
MH  - Polyomavirus/*pathogenicity/*physiology
MH  - Polyomavirus Infections/*virology
MH  - Tumor Virus Infections/*virology
RF  - 46
EDAT- 2001/02/24 12:00
MHDA- 2001/08/24 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1023/a:1008190504521 [doi]
PST - ppublish
SO  - Virus Genes. 2001 Jan;22(1):93-101. doi: 10.1023/a:1008190504521.