PMID- 11211839 OWN - NLM STAT- MEDLINE DCOM- 20021025 LR - 20121115 IS - 1001-5515 (Print) IS - 1001-5515 (Linking) VI - 17 IP - 4 DP - 2000 Dec TI - [The research advance of brain derived neurotrophic factor]. PG - 454-6, 460 AB - Recent research advances in neuroscience show that neurotrophic factors are proteins that affect selectively various kinds of neurons of CNS and PNS. Brain derived neurotrophic factor (BDNF) is another neurotrophic factor that was first reported by Barde, a German chemist, thirty years later after the nerve growth factor had been found out. BDNF plays an important role in the growth, development, differentiation, maintenance and regeneration of various types of neurons in the CNS and has potential application to the treatment of brain injury and neurodegenerative diseases such as Alzheimer's disease, Parkinson's syndrome, Huntington's chorea and amyotrophic lateral sclerosis. In this paper, the structure, function and potential clinical application of BDNF were reviewed. FAU - Liu, Z AU - Liu Z AD - Laboratory of Surgical Department, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041. FAU - Chen, J AU - Chen J LA - chi PT - English Abstract PT - Journal Article PT - Review PL - China TA - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi JT - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi JID - 9426398 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/chemistry/pharmacology/*physiology MH - Central Nervous System Diseases/drug therapy/physiopathology MH - Genetic Therapy MH - Neurons/physiology RF - 23 EDAT- 2001/02/24 12:00 MHDA- 2002/10/31 04:00 CRDT- 2001/02/24 12:00 PHST- 2001/02/24 12:00 [pubmed] PHST- 2002/10/31 04:00 [medline] PHST- 2001/02/24 12:00 [entrez] PST - ppublish SO - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2000 Dec;17(4):454-6, 460.