PMID- 11212085
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20191104
IS  - 0007-0785 (Print)
IS  - 0007-0785 (Linking)
VI  - 90
IP  - 1
DP  - 2001 Jan
TI  - The efficacy and safety of a homeopathic gel in the treatment of acute low back 
      pain: a multi-centre, randomised, double-blind comparative clinical trial.
PG  - 21-8
AB  - Acute low back pain is a very common condition in Western industrialised 
      countries. In most cases analgesics or topical medications are prescribed at 
      first encounter with the general practitioner (GP). The aim of this study was to 
      investigate whether the homeopathic gel Spiroflor SRL gel (SRL) is equally 
      effective and better tolerated than Cremor Capsici Compositus FNA (CCC) in 
      patients with acute low back pain. A multi-centre, randomised, double-blind, 
      controlled clinical trial was conducted in the practices of 19 GPs in the 
      districts of Bristol and Manchester, UK. One hundred and sixty-one subjects 
      suffering from acute low back pain were treated for one week either with SRL or 
      with CCC. Pain was scored on a 100 mm visual analogue scale (VAS). Main efficacy 
      parameter VAS reduction was compared between treatments. Evaluation of safety was 
      primarily based on the number of subjects with adverse events (AEs), withdrawals 
      due to an AE and adverse drug reactions (ADRs). The mean difference between the 
      VAS reduction in the SRL group and the CCC group adjusted for VAS at baseline and 
      age was -0.6mm (90% CI = -6.5-5.3mm). Fewer subjects in the SRL group (11%) 
      experienced an AE than in the CCC group (26%). The same applies to the number of 
      subjects with an ADR (3/81 = 4% vs 18/74 = 24%) and the number of subjects 
      withdrawn due to an ADR (0/81 = 0% vs 8/74 = 11%). In conclusion, SRL and CCC are 
      equally effective in the treatment of acute low back pain, however, SRL has a 
      better safety profile. Spiroflor SRL gel is preferable to Capsicum-based products 
      for the topical treatment of low back pain, because of the lower risk of adverse 
      effects.
FAU - Stam, C
AU  - Stam C
AD  - Regulatory Affairs Department, VSM Geneesmiddelen bv, Alkmaar, The Netherlands.
FAU - Bonnet, M S
AU  - Bonnet MS
FAU - van Haselen, R A
AU  - van Haselen RA
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - England
TA  - Br Homeopath J
JT  - The British homoeopathic journal
JID - 15730430R
RN  - 0 (Analgesics)
RN  - 0 (Gels)
SB  - IM
MH  - Administration, Cutaneous
MH  - Adult
MH  - Analgesics/administration & dosage/*therapeutic use
MH  - Double-Blind Method
MH  - Family Practice
MH  - Female
MH  - Gels
MH  - *Homeopathy
MH  - Humans
MH  - London
MH  - Low Back Pain/*drug therapy
MH  - Male
MH  - Pain Measurement
MH  - Treatment Outcome
EDAT- 2001/02/24 12:00
MHDA- 2001/05/01 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1054/homp.1999.0460 [doi]
PST - ppublish
SO  - Br Homeopath J. 2001 Jan;90(1):21-8. doi: 10.1054/homp.1999.0460.