PMID- 11213075
OWN - NLM
STAT- MEDLINE
DCOM- 20010308
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 71
IP  - 2
DP  - 2001 Jan 27
TI  - Fatal primary infection due to human herpesvirus 6 variant A in a renal 
      transplant recipient.
PG  - 288-92
AB  - We describe a fatal primary human herpesvirus 6 (HHV-6) variant A infection in a 
      kidney transplanted adult woman. On day 20 post transplantation (TX), after 
      rejection therapy, the patient presented an acute hemophagocytic syndrome with 
      hepatitis and central nervous system involvement. HHV-6 IgG and IgM antibodies 
      seroconversion was demonstrated. HHV-6 variant A was the sole pathogen detected 
      by nested PCR and/or culture in blood, bone marrow aspiration, liver biopsy, 
      cerebrospinal fluid and bronchoalveolar lavage. The graft was HHV-6 seropositive 
      and the patient was not transfused before day 28 post TX, suggesting that the 
      virus was transmitted by the graft. Despite immunoglobulins, ganciclovir and 
      foscarnet therapy, the HHV-6 infection progressed and led to severe aplasia. The 
      patient developed Aspergillus fumigatus pneumonia and died from fulminant 
      candidemia. This case demonstrated for the first time that HHV-6 variant A 
      primary infection can cause life-threatening disseminated infection in 
      immunosuppressed patients.
FAU - Rossi, C
AU  - Rossi C
AD  - Infectious Diseases Clinic, Department of Nephrology, Erasme Hospital, Universite 
      Libre de Bruxelles, Brussels, Belgium.
FAU - Delforge, M L
AU  - Delforge ML
FAU - Jacobs, F
AU  - Jacobs F
FAU - Wissing, M
AU  - Wissing M
FAU - Pradier, O
AU  - Pradier O
FAU - Remmelink, M
AU  - Remmelink M
FAU - Byl, B
AU  - Byl B
FAU - Thys, J P
AU  - Thys JP
FAU - Liesnard, C
AU  - Liesnard C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/blood
MH  - Fatal Outcome
MH  - Female
MH  - Genetic Variation
MH  - Herpesviridae Infections/epidemiology/*genetics
MH  - *Herpesvirus 6, Human/immunology
MH  - Histiocytosis, Non-Langerhans-Cell/virology
MH  - Humans
MH  - Immunocompromised Host
MH  - *Kidney Transplantation
MH  - Time Factors
EDAT- 2001/02/24 12:00
MHDA- 2001/03/10 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/10 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1097/00007890-200101270-00021 [doi]
PST - ppublish
SO  - Transplantation. 2001 Jan 27;71(2):288-92. doi: 10.1097/00007890-200101270-00021.