PMID- 11216753
OWN - NLM
STAT- MEDLINE
DCOM- 20010315
LR  - 20190628
IS  - 0003-4975 (Print)
IS  - 0003-4975 (Linking)
VI  - 71
IP  - 1
DP  - 2001 Jan
TI  - Beta-chemokine secretion patterns in relation to clinical course and outcome in 
      children after cardiopulmonary bypass: continuing the search to abrogate systemic 
      inflammatory response.
PG  - 233-7
AB  - BACKGROUND: Surgery involving cardiopulmonary bypass (CPB) is frequently 
      accompanied by a systemic inflammatory response partly triggered by neutrophils 
      and monocyte-macrophages. Certain cytokines that are powerful 
      leukocyte-chemotactic factors have recently been characterized and shown to be 
      important in evoking inflammatory responses: monocyte chemoattractant protein-1 
      (MCP-1) has monocyte-macrophage chemotactic activity, and 
      regulated-upon-activation normal T-cell expressed and secreted (RANTES) has a 
      potent chemoattractant activity for mononuclear phagocytes. This prospective 
      cohort study investigated possible roles of these chemokines in the inflammatory 
      response to CPB and relationships between the changes in chemokine levels and the 
      clinical course and outcome. METHODS: Systemic blood of 16 children undergoing 
      CPB was collected after induction of anesthesia (base line); at 15 minutes after 
      bypass onset; at CPB cessation; and at 1, 2, 4, 8, 12, and 24 hours afterward to 
      measure MCP-1 and RANTES. RESULTS: The significant changes of plasma beta 
      chemokine levels following CPB were associated with patient characteristics, 
      operative variables, and postoperative course. Cardiopulmonary bypass of more 
      than 2 hours, longer surgical times, inotropic support, and reoperation were 
      associated with higher MCP-1 levels and lower RANTES levels. CONCLUSIONS: Our 
      results suggest a relation between CPB-induced mediators and clinical effects, 
      implying pathogenic roles for chemokines following CPB. These molecules should be 
      considered as possible targets for therapeutic intervention.
FAU - Lotan, D
AU  - Lotan D
AD  - Department of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, 
      Israel.
FAU - Zilberman, D
AU  - Zilberman D
FAU - Dagan, O
AU  - Dagan O
FAU - Keller, N
AU  - Keller N
FAU - Ben-Abraham, R
AU  - Ben-Abraham R
FAU - Weinbroum, A A
AU  - Weinbroum AA
FAU - Harel, R
AU  - Harel R
FAU - Barzilay, Z
AU  - Barzilay Z
FAU - Paret, G
AU  - Paret G
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines)
SB  - IM
MH  - Adolescent
MH  - *Cardiac Surgical Procedures
MH  - *Cardiopulmonary Bypass
MH  - Chemokine CCL2/blood
MH  - Chemokine CCL5/metabolism
MH  - Chemokines/blood/*metabolism
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Heart Diseases/metabolism/surgery
MH  - Humans
MH  - Infant
MH  - Male
MH  - Systemic Inflammatory Response Syndrome/*physiopathology
EDAT- 2001/02/24 12:00
MHDA- 2001/03/17 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/03/17 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - S0003-4975(00)02020-8 [pii]
AID - 10.1016/s0003-4975(00)02020-8 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2001 Jan;71(1):233-7. doi: 10.1016/s0003-4975(00)02020-8.