PMID- 11216880
OWN - NLM
STAT- MEDLINE
DCOM- 20010412
LR  - 20190921
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 45
IP  - 2
DP  - 2001 Feb
TI  - Human leukocyte antigen-G-expressing cells differently modulate the release of 
      cytokines from mononuclear cells present in the decidua versus peripheral blood.
PG  - 94-9
AB  - PROBLEM: To better understand the role of human leukocyte antigen (HLA)-G in 
      regulating the T helper (Th)1/Th2 cytokine balance, one of key conditions in 
      determining the fate of pregnancy, we asked whether the presence of HLA-G protein 
      altered the release of cytokines from both decidual mononuclear cells and 
      peripheral blood mononuclear cells (PBMCs). METHOD OF STUDY: The amounts of 
      cytokines released from decidual mononuclear cells and PBMCs were compared in the 
      presence or absence of HLA-G-expressing cells. RESULTS: When cocultured with 
      HLA-G-expressing cells, the amounts of tumor necrosis factor-alpha and 
      interferon-gamma released from decidual mononuclear cells and PBMCs were 
      decreased, while the amounts of interleukin (IL)-4 from PBMCs was increased, with 
      IL-4 release from decidual mononuclear cells being unchanged. CONCLUSIONS: Upon 
      contact with HLA-G, decidual mononuclear cells, and PBMCs as well, modulate their 
      ability to release cytokines in a way that may shift the Th1/Th2 balance towards 
      relative Th2 dominance, suggesting a role for HLA-G in maintaining pregnancy.
FAU - Kanai, T
AU  - Kanai T
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, University of 
      Tokyo, Japan.
FAU - Fujii, T
AU  - Fujii T
FAU - Unno, N
AU  - Unno N
FAU - Yamashita, T
AU  - Yamashita T
FAU - Hyodo, H
AU  - Hyodo H
FAU - Miki, A
AU  - Miki A
FAU - Hamai, Y
AU  - Hamai Y
FAU - Kozuma, S
AU  - Kozuma S
FAU - Taketani, Y
AU  - Taketani Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Culture Media)
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Cell Line
MH  - Culture Media
MH  - Cytokines/*metabolism
MH  - Decidua/*metabolism
MH  - Female
MH  - HLA Antigens/analysis/*physiology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/analysis/*physiology
MH  - Humans
MH  - Interferon-gamma/analysis/metabolism
MH  - Interleukin-4/analysis/metabolism
MH  - Leukocytes, Mononuclear/*metabolism
MH  - Tumor Necrosis Factor-alpha/analysis/metabolism
EDAT- 2001/02/24 12:00
MHDA- 2001/04/17 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/04/17 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
AID - 10.1111/j.8755-8920.2001.450205.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2001 Feb;45(2):94-9. doi: 10.1111/j.8755-8920.2001.450205.x.