PMID- 11217450
OWN - NLM
STAT- MEDLINE
DCOM- 20010405
LR  - 20061115
IS  - 0070-4113 (Print)
IS  - 0070-4113 (Linking)
VI  - 84
DP  - 2000
TI  - [Morphology and biology of invasion with Barret's carcinoma as an example].
PG  - 62-8
AB  - In order to determine the molecular genetic alterations associated with tumor 
      invasion, Barrett's adenocarcinoma and its non-invasive precursor lesions were 
      investigated by comparative genomic hybridization (CGH), fluorescence in situ 
      hybridization (FISH), and loss of heterozygosity (LOH). Along the 
      metaplasia-dysplasia-carcinoma sequence in Barrett's adenocarcinoma gains on 7q, 
      8q, 20q, 2p, 10q and 17q, and losses on Y, 4q, 5q, 9p 18q and 14q became steadily 
      more frequent. FISH demonstrated increasing DNA copy of numbers of c-erbB-2, 
      20q13.2 (AIB), c-myc and cyclin D1 during the development of Barrett's 
      adenocarcinoma, and LOH confirmed DNA losses on 5q21 (APC) and 18q (DCC). Some of 
      the chromosomal changes of the non-invasive precursor lesions were significantly 
      different from the alterations detected in invasive carcinoma. Although molecular 
      pathology may be used as diagnostic adjunct in future, the histopathological 
      determination of invasion remains the most important diagnostic criterion of 
      malignancy in Barrett's adenocarcinoma.
FAU - Werner, M
AU  - Werner M
AD  - Institut fur Allgemeine Pathologie und Pathologische Anatomie, Technische 
      Universitat Munchen, Klinikum rechts der Isar, Munchen.
FAU - Walch, A
AU  - Walch A
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Morphologie und Biologie der Invasion am Beispiel des Barrett-Karzinoms.
PL  - Germany
TA  - Verh Dtsch Ges Pathol
JT  - Verhandlungen der Deutschen Gesellschaft fur Pathologie
JID - 7503704
SB  - IM
MH  - Adenocarcinoma/*genetics/*pathology
MH  - Barrett Esophagus/*genetics/*pathology
MH  - *Chromosome Aberrations
MH  - Chromosome Mapping
MH  - Chromosomes, Human
MH  - Esophageal Neoplasms/*genetics/*pathology
MH  - Humans
MH  - Loss of Heterozygosity
MH  - Neoplasm Invasiveness
EDAT- 2001/02/24 12:00
MHDA- 2001/04/06 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/04/06 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
PST - ppublish
SO  - Verh Dtsch Ges Pathol. 2000;84:62-8.