PMID- 11218403
OWN - NLM
STAT- MEDLINE
DCOM- 20010419
LR  - 20201208
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 59
IP  - 2
DP  - 2001 Feb
TI  - [Selection of antibiotics and planning of eradication for H. pylori infection].
PG  - 308-13
AB  - There is general agreement that H. pylori should be eradicated in patients with 
      peptic ulcers. But the optimal therapeutical regimen to be used still remains a 
      matter for many investigations. An increase in the prevalence of 
      antibiotic-resistant H. pylori strains has been reported recently. The 
      recommended drugs for the eradication in Japan are clarithromycin (CAM) and 
      amoxicillin (AMPC) because metronidazole (MNZ) is anti-parasites drug in Japan. A 
      total of 392 H. pylori strains in the last twelve years were tested for 
      sensitivity to CAM, MNZ, and AMPC. The Primary resistance of H. pylori to CAM, 
      MNZ, and AMPC were found in 10.2%, 26.5%, and 0.3% strains, respectively. The 
      resistant strains to CAM were gradually increasing in the last few years. The 
      eradication therapies which do not increase antibiotics resistant strains after 
      eradication failure were reported. The recommendation for eradication in patients 
      with peptic ulcer disease includes those with bleeding ulcers. The pretreatment 
      with proton pump inhibitors (PPI) does not influence the success of PPI-based 
      triple therapy in eradicating H. pylori.
FAU - Murakami, K
AU  - Murakami K
AD  - Second Department of Internal Medicine, Oita Medical University.
FAU - Satoh, R
AU  - Satoh R
FAU - Okimoto, T
AU  - Okimoto T
FAU - Kagawa, J
AU  - Kagawa J
FAU - Fujioka, T
AU  - Fujioka T
FAU - Kodama, M
AU  - Kodama M
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Benzimidazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - 140QMO216E (Metronidazole)
RN  - 32828355LL (Rabeprazole)
RN  - 804826J2HU (Amoxicillin)
RN  - H1250JIK0A (Clarithromycin)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Amoxicillin/administration & dosage/pharmacology
MH  - Benzimidazoles/administration & dosage
MH  - Clarithromycin/administration & dosage/pharmacology
MH  - Drug Administration Schedule
MH  - Drug Resistance, Microbial
MH  - Drug Therapy, Combination/administration & dosage
MH  - Enzyme Inhibitors/administration & dosage
MH  - Helicobacter Infections/*drug therapy/microbiology
MH  - *Helicobacter pylori/drug effects
MH  - Humans
MH  - Metronidazole/administration & dosage/pharmacology
MH  - Omeprazole/administration & dosage
MH  - Peptic Ulcer/drug therapy/microbiology
MH  - Proton Pump Inhibitors
MH  - Rabeprazole
RF  - 15
EDAT- 2001/02/24 12:00
MHDA- 2001/04/21 10:01
CRDT- 2001/02/24 12:00
PHST- 2001/02/24 12:00 [pubmed]
PHST- 2001/04/21 10:01 [medline]
PHST- 2001/02/24 12:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2001 Feb;59(2):308-13.