PMID- 11221875
OWN - NLM
STAT- MEDLINE
DCOM- 20010315
LR  - 20081121
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 61
IP  - 3
DP  - 2001 Feb 1
TI  - Interleukin-18 (IL-18) synergizes with IL-2 to enhance cytotoxicity, 
      interferon-gamma production, and expansion of natural killer cells.
PG  - 884-8
AB  - We investigated the in vitro effects of combining interleukin-18 (IL-18) and IL-2 
      on human lymphocytes. The combined use of these two cytokines synergistically 
      enhanced the proliferation, cytolytic activity, and interferon-gamma production 
      of peripheral blood mononuclear cells. Phenotypic analysis revealed a 
      preferential expansion of CD56+CD3- cells and an up-regulation of IL-2 
      receptor-alpha expression on natural killer cells. Isolated natural killer cells 
      showed a substantial increase in proliferation and cytotoxicity compared with 
      CD4+ and CD8+ T cells. The combined use of IL-18 and IL-2 should be considered a 
      viable strategy to induce an antitumor response in vivo.
FAU - Son, Y I
AU  - Son YI
AD  - Department of Surgery, University of Pittsburgh Cancer Institute, Pennsylvania 
      15261, USA.
FAU - Dallal, R M
AU  - Dallal RM
FAU - Mailliard, R B
AU  - Mailliard RB
FAU - Egawa, S
AU  - Egawa S
FAU - Jonak, Z L
AU  - Jonak ZL
FAU - Lotze, M T
AU  - Lotze MT
LA  - eng
GR  - CA 68067/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-2)
RN  - 0 (Receptors, Interleukin-2)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - CD4-Positive T-Lymphocytes/drug effects/immunology/metabolism
MH  - CD8-Positive T-Lymphocytes/drug effects/immunology/metabolism
MH  - Cell Division/drug effects
MH  - Cytotoxicity, Immunologic/drug effects
MH  - Drug Synergism
MH  - Humans
MH  - Interferon-gamma/*biosynthesis
MH  - Interleukin-18/*pharmacology
MH  - Interleukin-2/*pharmacology
MH  - Killer Cells, Natural/drug effects/*immunology/metabolism
MH  - Leukocytes, Mononuclear/drug effects/immunology/metabolism
MH  - Lymphocyte Activation/drug effects
MH  - Lymphocytes/drug effects/immunology/metabolism
MH  - Lymphoma, B-Cell/immunology
MH  - Receptors, Interleukin-2/biosynthesis
MH  - Tumor Cells, Cultured
MH  - Up-Regulation/drug effects
EDAT- 2001/02/28 10:00
MHDA- 2001/03/17 10:01
CRDT- 2001/02/28 10:00
PHST- 2001/02/28 10:00 [pubmed]
PHST- 2001/03/17 10:01 [medline]
PHST- 2001/02/28 10:00 [entrez]
PST - ppublish
SO  - Cancer Res. 2001 Feb 1;61(3):884-8.